New therapeutic strategy of atherosclerosis targeting immune system for inhibition of angiogenesis
Project/Area Number |
22790372
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Experimental pathology
|
Research Institution | Tohoku University |
Principal Investigator |
NAKANO Makoto 東北大学, 大学院・医学系研究科, 助教 (30513551)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 炎症 / 動脈硬化 / 血管新生 / OX40 |
Research Abstract |
OX40/OX40 ligand (OX40L)system, which activates T cells, decreased atherosclerotic lesion through inhibition of vasa vasorum angiogenesis in mice. Bone marrow transplantation of mice revealed that OX40L system in bone marrow did not contribute to this phenomenon.
|
Report
(3 results)
Research Products
(4 results)