New therapeutic strategy of atherosclerosis targeting immune system for inhibition of angiogenesis

• Project/Area Number: 22790372
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Experimental pathology
• Research Institution: Tohoku University
• Principal Investigator: NAKANO Makoto 東北大学, 大学院・医学系研究科, 助教 (30513551)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 炎症 / 動脈硬化 / 血管新生 / OX40

Research Abstract

OX40/OX40 ligand (OX40L)system, which activates T cells, decreased atherosclerotic lesion through inhibition of vasa vasorum angiogenesis in mice. Bone marrow transplantation of mice revealed that OX40L system in bone marrow did not contribute to this phenomenon.

Research Products

• [Journal Article] OX40 ligand plays an important role in the development of atherosclerosis through vasa vasorum neovascularization (2010)
  • Author(s): Nakano M, Shimokawa H, et. al
  • Journal Title: Cardiovascular Research Volume: 88 Pages: 539-546
  • Peer Reviewed
• [Presentation] Genetic Deletion of OX40 Ligand Suppresses the Development of Atherosclerosis in Apolipoprotein E-Deficient Mice (2010)
  • Author(s): 中野誠、下川宏明, 他
  • Organizer: World Congress of the ISHR 2010
  • Place of Presentation: 京都国立京都国際会館
  • Year and Date: 2010-05-16
• [Remarks]
  • URL: http://www.cardio.med.tohoku.ac.jp/index.html
• [Remarks]
  • URL: http://www.cardio.med.tohoku.ac.jp/index.html