Development of a novel technique for myoblast transplantation that is capable of preventing life-threatening arrhythmias and of dramatically restoring cardiac contractility
Project/Area Number |
22790373
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Experimental pathology
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Research Institution | Tohoku University |
Principal Investigator |
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 再生医学 / 心筋 / 心不全 / 再生治療 / 筋芽細胞 / 再生医療 / 不整脈 / ミオシン / 収縮力 |
Research Abstract |
We have succeeded in developing a novel technique for cardiac regeneration that excels other methods both in efficacy and in safety. Conventional myoblast transplantation, one of the most promising myocardial reconstructive approaches ever,was plagued by life-threatening arrhythmias and inadequate contractile restoration. Our studies suggest that these problems are simultaneously conquered by transducing myoblasts with protein X prior to implantation. This holds promise for yet earlier realization of a revolutionary heart regenerative therapy with much better prognosis than ever before.
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Report
(3 results)
Research Products
(2 results)