Development of a novel technique for myoblast transplantation that is capable of preventing life-threatening arrhythmias and of dramatically restoring cardiac contractility

Research Project

Project/Area Number	22790373
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Experimental pathology
Research Institution	Tohoku University
Principal Investigator	KUMAGAI Hiroyuki 東北大学, 大学院・医学系研究科, 助教 (20321945)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	再生医学 / 心筋 / 心不全 / 再生治療 / 筋芽細胞 / 再生医療 / 不整脈 / ミオシン / 収縮力
Research Abstract	We have succeeded in developing a novel technique for cardiac regeneration that excels other methods both in efficacy and in safety. Conventional myoblast transplantation, one of the most promising myocardial reconstructive approaches ever,was plagued by life-threatening arrhythmias and inadequate contractile restoration. Our studies suggest that these problems are simultaneously conquered by transducing myoblasts with protein X prior to implantation. This holds promise for yet earlier realization of a revolutionary heart regenerative therapy with much better prognosis than ever before.