| Project/Area Number |
22790380
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Kyoto University |
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Principal Investigator |
AOKI Koji 京都大学, 医学研究科, 助教 (40402862)
|
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | CDX2 / 細胞増殖 / 大腸癌 / 癌抑制遺伝子 / 転写 / 細胞生存 |
|---|
| Research Abstract |
CDX2 is a homebox transcription factor that is expressed specifically in the intestinal epithelial cells. We have previously shown that CDX2 supresses colonic tumorigensis, using a knockout mouse model. In this study, we have found that CDX2 suppresses proliferation of colon cancer cells through its non-transcriptional function, wheares it acts as a transcription factor. The block of cell proliferation caused by CDX2 is mediated partilly through increased level of p27 protein, a CDK inhibitor. In addition, we have found ubiqutin E1-like enzyme ATG7 as a protein interacting with CDX2, and that CDX2 stimulates autophagy. Interestingly, CDX2 induces a kind of cell death through autophagy. Thease results have suggested that CDX2 suppresses colonic tumorigensis through ATG7-mediated stimulation of autophagy.
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