Interaction between p53 and FoxO1 transcription factor in the anti-aging effect of calorie restriction
| Project/Area Number |
22790383
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Nagasaki University |
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Principal Investigator |
HAYASHI Hiroko 長崎大学, 大学院・医歯薬学総合研究科, 助教 (40513221)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 動物 / 老化 / カロリー制限 / p53 / FoxO転写因子 / FoxO 転写因子 |
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| Research Abstract |
This study was conducted to elucidate an interaction between p53 and FoxO1 transcription factor in the anti-aging effect of calorie restriction (CR). We confirmed that CR reduced the protein expression level of p53 in the tissues and age-related increases in the mRNA levels of Cdkn2a and p21, those are known to be regulated by p53. During the period of the present study, we could not evaluated the interaction of p53 in vivo, because of difficulty of propagation of p53 (m/+) mice, in which an active form of p53 is overexpressed. However, the present study demonstrated that FoxO3 is needed for the life-extending effectof CR; by contrast, FoxO1 plays an important role for the anti-neoplastic effect ofCR.
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Report
(4 results)
Research Products
(12 results)
