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Interaction between p53 and FoxO1 transcription factor in the anti-aging effect of calorie restriction

Research Project

Project/Area Number 22790383
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionNagasaki University

Principal Investigator

HAYASHI Hiroko  長崎大学, 大学院・医歯薬学総合研究科, 助教 (40513221)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords動物 / 老化 / カロリー制限 / p53 / FoxO転写因子 / FoxO 転写因子
Research Abstract

This study was conducted to elucidate an interaction between p53 and FoxO1 transcription factor in the anti-aging effect of calorie restriction (CR). We confirmed that CR reduced the protein expression level of p53 in the tissues and age-related increases in the mRNA levels of Cdkn2a and p21, those are known to be regulated by p53. During the period of the present study, we could not evaluated the interaction of p53 in vivo, because of difficulty of propagation of p53 (m/+) mice, in which an active form of p53 is overexpressed. However, the present study demonstrated that FoxO3 is needed for the life-extending effectof CR; by contrast, FoxO1 plays an important role for the anti-neoplastic effect ofCR.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (12 results)

All 2012 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (7 results)

  • [Journal Article] Acute stress response modified by modest inhibition of growth hormone axis : apotential machinery of the anti-aging effect of calorie restriction2011

    • Author(s)
      Komatsu T, Trindade LS, Chiba T, Hayashi H, Henmi T, Ushiroda Y, Mori R, Shimokawa I
    • Journal Title

      Mechanisms of Ageing and Development

      Volume: 132 Issue: 3 Pages: 103-109

    • DOI

      10.1016/j.mad.2011.01.002

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a bioassay to screen for chemicals mimicking the anti-aging effects of calorie restriction2010

    • Author(s)
      Chiba T, Hayashi H
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 401 Issue: 2 Pages: 213-218

    • DOI

      10.1016/j.bbrc.2010.09.032

    • NAID

      120006984912

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] FoxOl is involved in the antineoplastic effect of calorie restriction2010

    • Author(s)
      Yamaza H, Hayashi H
    • Journal Title

      Aging Cell

      Volume: 9 Issue: 3 Pages: 372-382

    • DOI

      10.1111/j.1474-9726.2010.00563.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a bioassay to screen for chemicals mimicking the anti-aging effects of calorie restriction.2010

    • Author(s)
      Chiba T, Hayashi H, 他
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 401 Pages: 213-218

    • NAID

      120006984912

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FoxOl is involved in the antineoplastic effect of calorie restriction.2010

    • Author(s)
      Yamaza H, Hayashi H, 他
    • Journal Title

      Aging Cell

      Volume: 9 Pages: 372-382

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] International Symposium of Asian Association of Aging Research 2012 in Fukuoka - Biology of Aging and Disorders2012

    • Author(s)
      Komatsu T, Mori R, Hayashi H, Kamohara R, Kim SE, Chiba T
    • Organizer
      Shimokawa I FoxO1 plays a key role in anti-neoplastic effect but not lifespan extension of Calorie Restriction in mice
    • Place of Presentation
      Fukuoka, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] カロリー制限の抗腫瘍効果と寿命延長効果における FoxO1 の役割(優秀演題に選出)2012

    • Author(s)
      小松 利光、森 亮一、林 洋子、蒲原 涼太郎、金 湘殷、千葉 卓哉、下川 功
    • Organizer
      第12回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] FoxO1 plays a key role in anti-neoplastic effect but not lifespan extension of Calorie Restriction in mice2012

    • Author(s)
      Komatsu T, Mori R, Hayashi H
    • Organizer
      International Symposium of Asian Association of Aging Research 2012
    • Place of Presentation
      Fukuoka
    • Related Report
      2012 Annual Research Report
  • [Presentation] カロリー制限の抗腫瘍効果と寿命延長効果におけるFoxO1の役割2012

    • Author(s)
      小松 利光、森 亮一、林 洋子
    • Organizer
      第12回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] カロリー制限の抗腫瘍効果におけるFoxO1の役割2011

    • Author(s)
      小松利光, 林洋子, 他
    • Organizer
      日本基礎老化学会第34回大会(ポスターセッション)
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2011-06-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] カロリー制限の抗腫瘍効果と寿命延長効果における FoxO1 の役割(優秀演題に選出)2011

    • Author(s)
      千葉 卓哉、小松 利光、森 亮一、林 洋子、下川 功
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] カロリー制限の抗腫瘍効果における FoxO1の役割2011

    • Author(s)
      小松 利光、森 亮一、林 洋子、蒲原 涼太郎、Kim Sang Eun、粕谷 泰祐、永冨 裕子、千葉 卓哉、下川 功
    • Organizer
      第34回日本基礎老化学会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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