| Project/Area Number |
22790392
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Institute for Developmental Research, Aichi Human Service Center |
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Principal Investigator |
ISHII Sanae (ISHII HASEGAWA Sanae) 愛知県心身障害者コロニー発達障害研究所, 病理学部, リサーチレジデント (40435863)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 骨髄内移植 / ミクログリア / 脳老化病態 / 骨髄内骨髄移植 / 骨髄由来細胞 / 脈絡叢 / SAMP10マウス |
|---|
| Research Abstract |
After syngeneic intra-bone marrow-bone marrow transplantation(IBM-BMT), marrow-derived cells rapidly appeared in the leptomeninges, choroid plexus, perivascular regions and circumventricular organs, which lack the blood-brain barrier(BBB). Marrow-derived cells entered several small discrete regions of the brain parenchyma, although they did not enter the remaining major part. Marrow-derived cells exhibited ramified morphology and expressed Iba-1 but not GFAP, CNPase or NeuN, indicative of the myeloid lineage. In chimeras in which SAMP10 mice were recipients, a larger number of donor-derived cells entered more regions than in chimeras in which B6 mice were recipients. After allogeneic IBM-BMT, the learning ability of old SAMP10 mice was not ameliorated, which may be due to the failure in the recovery of peripheral T cells after IBM-BMT.
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