Role of Lipocalin 2 during malaria infection

• Project/Area Number: 22790394
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Parasitology (including Sanitary zoology)
• Research Institution: Osaka University
• Principal Investigator: COBAN Cevayir 大阪大学, 免疫学フロンティア研究センター, 特任准教授 (00397712)
• Co-Investigator(Renkei-kenkyūsha): AKIRA Shizuo 大阪大学, 免疫学フロンティア研究センター, 教授 (50192919) ; HORII Toshihiro 大阪大学, 微生物病研究所, 教授 (80142305) ; ISHII Ken 大阪大学, 免疫学フロンティア研究センター, 教授 (00448086)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: マラリア / リポカン2 / 鉄代謝 / 感染症 / 貧血 / プラスモディウム・ヨエリ / 免疫学 / mammalian siderophore / リポカリン2 / ディフェロキサミン

Research Abstract

Malaria is one of the most deadly infectious diseases in the world, with no effective vaccine yet that many of the host immune responses against malaria parasites remain unclear. Plasmodium parasites feed and multiply within erythrocytes, and their egress from these cells results in various degrees of anemia. Little is known about how host iron homeostasis affects the immune system during malaria. In this research we found that Lipocalin 2, a known early innate immune response molecule, is abundantly secreted during mouse malaria infection, and is required for the clearance of parasites. Therefore, results of this research may lead to a new understanding of Lcn2-mediated anti-malarial immunity through the modulation of host iron metabolism.

Research Products

• [Journal Article] The origins of African Plasmodium vivax ; insights from mitochondrial genome sequencing (2011)
  • Author(s): Culleton R, Coban C, Yildiz Zeyrek F, Cravo P, Kaneko A, Randrianarivelojosia M, Andrianaranjaka V, Kano S, Farnert A, Arez A, Sharp PM, Carter R, Tanabe K.
  • Journal Title: PLoS ONE Volume: 6(12)
  • NAID: 120006985193
• [Journal Article] Serologic Markers in Relation to Parasite Exposure History Help to Estimate Transmission Dynamics of Plasmodium vivax (2011)
  • Author(s): Yildiz Zeyrek F, Palacpac N, Yuksel F, Yagi M, Honjo K, Fujita Y, Arisue N, Takeo S, Tanabe K, Horii T, Tsuboi T, Ishii KJ, Coban C*
  • Journal Title: PLoS ONE Volume: 6(11)
• [Journal Article] Novel Strategies to Improve DNA Vaccine Immunogenicity (2011)
  • Author(s): Coban C, Kobiyama K, Aoshi T, Takeshita F, Horii T, Akira S, Ishii KJ
  • Journal Title: Review, Current Gene Therapy Volume: 11(6) Pages: 479-484
• [Journal Article] DNA released from dying host cells mediates aluminum adjuvant activity (2011)
  • Author(s): Marichal T, Ohata K, Bedoret D, Mesnil C, Sabatel C, Kobiyama K, Lekeux P, Coban C, Akira S, Ishii KJ, Bureau F, Desmet CJ
  • Journal Title: Nature Medicine Volume: 17(8) Pages: 996-1002
• [Journal Article] Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms (2011)
  • Author(s): Kuroda E, Ishii KJ, Uematsu S, Ohata K, Coban C, Akira S, Aritake K, Urade Y, Morimoto Y
  • Journal Title: Immunity Volume: 34(4) Pages: 514-526
• [Journal Article] マラリアヘモゾインに対するTLR9での反応と免疫増強効果 (2011)
  • Author(s): 津久井利広、Coban, Cevayir, 八木正典、大畑敬一、猪狩義勝、福井真人、堀井俊宏、審良静男、石井健
  • Journal Title: 臨床免疫・アレルギー科 Volume: 55(1) Pages: 28-34
• [Journal Article] Novel Adjuvant : A nanocrystal from malaria parasites (2011)
  • Author(s): Coban C, Ohata K, Igari Y, Kato M, Tsukui T.
  • Journal Title: Adjuvant Volume: (CMC Publishing) Pages: 107-115
• [Journal Article] Biomedical polymers subvert dendritic cell function and adhesion through the activation of multiple Toll-like receptor signaling cascades (2011)
  • Author(s): Shokouhi B, Coban C, Hasirci V, Aydin E, Dhanasingh A, Shi N, Koyama S, Akira S, Zenke M, Sechi AS
  • Journal Title: Biomaterials Volume: 31(22) Pages: 5759-5771
• [Journal Article] The origins of African Plasmodium vivax ; insights from mitochondrial genome sequencing (2011)
  • Author(s): Culleton R, Coban C, Yildiz Zeyrek F, Cravo P, Kaneko A, Randrianarivelojosia M, Andrianaranjaka V, Kano S, Famert A, Arez A, Sharp PM, Carter R, Tanabe K
  • Journal Title: PLoS ONE Volume: 6(12) Issue: 12 Pages: e29137-e29137
  • DOI: 10.1371/journal.pone.0029137
  • NAID: 120006985193
  • Peer Reviewed
• [Journal Article] Serologic Markers in Relation to Parasite Exposure History Help to Estimate Transmission Dynamics of Plasmodium vivax (2011)
  • Author(s): Yildiz Zeyrek F, Palacpac N, Yuksel F, Yagi M, Honjo K, Fujita Y, Arisue N, Takeo S, Tanabe K, Horii T, Tsuboi T, Ishii KJ, Coban C
  • Journal Title: PLoS ONE Volume: 6(11) Issue: 11 Pages: e28126-e28126
  • DOI: 10.1371/journal.pone.0028126
  • Peer Reviewed
• [Journal Article] Novel Strategies to Improve DNA Vaccine Immunogenicity (2011)
  • Author(s): Coban C, Kobiyama K, Aoshi T, Takeshita F, Horii T, Akira S, Ishii KJ
  • Journal Title: Current Gene Therapy Volume: 11(6) Pages: 479-484
  • Peer Reviewed
• [Journal Article] Novel Adjuvant : A nanocrystal from malaria parasites (2011)
  • Author(s): Coban C, Ohata K, Igari Y, Kato M, Tsukui T
  • Journal Title: Book chapter in Adjuvant (Edited by Kouichi Yamanishi and Ken J.Ishii)(CMC Publishing) Volume: 2.7 Pages: 107-115
  • Peer Reviewed
• [Journal Article] Limited polymorphism of the Plasmodium vivax merozoite surface protein 1 gene in isolates from Turkey (2010)
  • Author(s): Yildiz Zeyrek F, Tachibana S, Yuksel F, Doni N, Palacpac N, Arisue N, Horii T, Coban C, Tanabe K
  • Journal Title: American Journal of Tropical Medicine and Hygiene Volume: 83(6) Pages: 1230-1237
• [Journal Article] TLR9 and Endogenous Adjuvants of the Whole Blood-stage Malaria Vaccine (2010)
  • Author(s): Coban C*, Horii T, Akira S, Ishii KJ
  • Journal Title: Review, Expert Reviews of Vaccines Volume: (in press)
• [Journal Article] The malarial metabolite hemozoin and its potential use as a vaccine adjuvant (2010)
  • Author(s): Coban C*, Yagi M, Ohata K, Igari Y, Tsukui T, Horii T, Ishii KJ, Akira S
  • Journal Title: Review, Allergology International Volume: 59(2)(in press)
  • NAID: 10029669847
• [Journal Article] Immunogenicity of Whole Parasite Vaccines Against Plasmodium falciparum Involves Malarial Hemozoin and Host TLR9 (2010)
  • Author(s): Coban C, Igari Y, Yagi M, Reimer T, Koyama S, Aoshi T, Ohata K, Tsukui T, Takeshita F, Sakurai K, Ikegami T, Nakagawa A, Horii T, Nunez G, Ishii KJ, Akira S
  • Journal Title: Cell Host and Microbe Volume: 7(1) Pages: 50-61
• [Presentation] Novel mechanism of nanocrystal adjuvants ; lessons from malaria parasites and their metabolites (2012)
  • Author(s): Coban C
  • Organizer: 第81回日本寄生虫学会大会
  • Place of Presentation: 兵庫医科大学(兵庫県.
• [Presentation] Novel mechanism of nanocrystal adjuvants ; lessons from malaria parasites and their metabolites (2012)
  • Author(s): Coban C.
  • Organizer: World Immune Regulation Meeting(WIRM)-VI
  • Place of Presentation: Davos, SWITZERLAND
• [Presentation] Novel mechanism of nanocrystal adjuvants ; lessons from malaria parasites and their metabolites (2012)
  • Author(s): Coban C.
  • Organizer: The 5^<th> Immunoparasitology Meeting
  • Place of Presentation: 大阪大学(大阪府)
• [Presentation] Novel mechanism of nanocrystal adjuvants ; lessons from malaria parasites and their metabolites (2012)
  • Author(s): Coban C
  • Organizer: 第81回日本寄生虫学会大会
  • Place of Presentation: 兵庫医科大学(兵庫県)(招待講演)
• [Presentation] Novel mechanism of nanocrystal adjuvants ; lessons from malaria parasites and their metabolites (2012)
  • Author(s): Coban C
  • Organizer: World Immune Regulation Meeting (WIRM)-VI
  • Place of Presentation: Davos, SWITZERLAND(招待講演)
• [Presentation] Novel mechanism of nanocrystal adjuvants ; lessons from malaria parasites and their metabolites (2012)
  • Author(s): Coban C
  • Organizer: The 5^<th> Immunoparasitology Meeting
  • Place of Presentation: 大阪大学(大阪府)(招待講演)
• [Presentation] Innate nanocrsytals and their adjuvant properties (2011)
  • Author(s): Coban C.
  • Organizer: Department Center for Infectious Medicine(CIM)
  • Place of Presentation: Huddinge Campus, Karolinska Institute, Stockholm, SWEDEN
  • Year and Date: 2011-11-10
• [Presentation] Innate nanocrsytals and their adjuvant properties (2011)
  • Author(s): Coban C
  • Organizer: Invited Lecture at the Department Center for Infectious Medicine (CIM), Huddinge Campus
  • Place of Presentation: Karolinska Institute, Stockholm, SWEDEN(招待講演)
  • Year and Date: 2011-11-10
• [Presentation] Innate Immune responses to malaria parasites (2011)
  • Author(s): Coban C.
  • Organizer: Department of Microbiology, Tumor and Cell Biology(MTC)
  • Place of Presentation: Solna Campus, Karolinska Institute, Stockholm, SWEDEN
  • Year and Date: 2011-11-08
• [Presentation] Innate Immune responses to malaria parasites (2011)
  • Author(s): Coban C
  • Organizer: Invited Lecture at the Department of Microbiology, Tumor and Cell Biology (MTC), Solna Campus
  • Place of Presentation: Karolinska Institute, Stockholm, SWEDEN(招待講演)
  • Year and Date: 2011-11-08
• [Presentation] Lipocalin 2 and the iron metabolism during malaria infection (2011)
  • Author(s): Coban C, Zhao H, Yagi M, Aoshi T, Horii T, Ishii KJ, Akira S
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉県)
• [Presentation] Lipocalin 2 and the iron metabolism during malaria infection (2011)
  • Author(s): Coban C.
  • Organizer: Nagasaki Symposium on Malaria Biology 2011(II)
  • Place of Presentation: 長崎大学(長崎県)
• [Presentation] Underlying mechanism of nanocrystals' s vaccine adjuvant properties (2011)
  • Author(s): Coban C.
  • Organizer: Advances in Immunology and Cancer Biology
  • Place of Presentation: Bogazici University, Istanbul, TURKEY
• [Presentation] Lipocalin 2 and the iron metabolism during malaria infection (2011)
  • Author(s): Coban C
  • Organizer: Nagasaki Symposium on Malaria Biology 2011 (II)
  • Place of Presentation: 長崎大学(長崎県)(招待講演)
• [Presentation] Underlying mechanism of nanocrystals's vaccine adjuvant properties (2011)
  • Author(s): Coban C
  • Organizer: Advances in Immunology and Cancer Biology
  • Place of Presentation: Bogazici University, Istanbul, TURKEY(招待講演)
• [Presentation] Lipocalin 2 and the iron metabolism during malaria infection (2011)
  • Author(s): Coban C, Zhao H, Yagi M, Aoshi T, Horii T, Ishii KJ, Akira S
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉県)(Oral presentation)
• [Presentation] Underlying Mechanisms of Crystal's Vaccine Adjuvant Properties (2010)
  • Author(s): Coban C
  • Organizer: Immunological Mechanisms of Vaccination, Keystone Symposia (Chair person)
  • Place of Presentation: Hotel Sheraton, Seattle, WA, USA.
  • Year and Date: 2010-10-28
• [Presentation] A Nanocrystal from Malaria Parasite Hemozoin : From Malaria Infection to Vaccine Adjuvant (2010)
  • Author(s): Coban C.
  • Organizer: International Vaccine Institute(IVI)
  • Place of Presentation: Seoul, KOREA
  • Year and Date: 2010-10-20
• [Presentation] A Nanocrystal from Malaria Parasite Hemozoin : From Malaria Infection to Vaccine Adjuvant (2010)
  • Author(s): Coban C
  • Organizer: IVI Seminar Series
  • Place of Presentation: International Vaccine Institute (IVI), Seoul, KOREA(Invited Lecture)
  • Year and Date: 2010-10-20
• [Remarks]
  • URL: http://www.ifrec.osaka-u.ac.jp/jpn/laboratory/malariaimmunology/index.php
• [Remarks]
  • URL: http://www.ifrec.osaka-u.ac.jp/en/laboratory/malariaimmunology/index.php
• [Remarks]
  • URL: http://www.ifrec.osaka-u.ac.jp/en/laboratory/malariaimmunology/index.php