Regulatory gene expression by cohesin in malaria parasite

• Project/Area Number: 22790397
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Parasitology (including Sanitary zoology)
• Research Institution: Nagasaki University
• Principal Investigator: YAHATA Kazuhide 長崎大学, 熱帯医学研究所, 助教 (40467965)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: マラリア / エピジェネティック / インスレーター / マラリア原虫 / コヒーシン

Research Abstract

The new evidence is emerging suggesting that the cohesin complex is involved in the regulation of gene expression in yeast and mammals. However, a precise role for the cohesion complex in the regulation of gene expression remains completely unexplored in malaria parasite. Thus we cloned cohesin from malaria parasite and generated the cohesin-tagged transgenic parasite to assess the cohesin distribution in the genome. Cohesin mapping would reveal the gene expression mechanism of different developmental stages between mammalian host and mosquito of malaria parasite.

Research Products

• [Presentation] Time-lapse imagingを用いたマラリア原虫の赤血球侵入時における動態観察 (2011)
  • Author(s): 矢幡一英、Richard Culleton、金子修
  • Organizer: 第80回日本分子寄生虫学会大会
  • Place of Presentation: 東京慈恵会医科大学
  • Year and Date: 2011-07-17
• [Presentation] Time-lapse imagingを用いたマラリア原虫の赤血球侵入時における動態観察 (2011)
  • Author(s): 矢幡一英、Richard Culleton、金子修
  • Organizer: 第80回日本分子寄生虫学会大会
  • Place of Presentation: 東京慈恵会医科大学(東京都)
  • Year and Date: 2011-07-17
• [Remarks]
  • URL: http://www.tm.nagasaki-u.ac.jp/protozoology/Member-KY-J.htm