| Project/Area Number |
22790405
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Kyoto University |
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Principal Investigator |
HARA Hideki 京都大学, 医学研究科, 助教 (30456892)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 感染免疫 / Listeria monocytogenes / Listeriolysin O / Inflammasome |
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| Research Abstract |
Inflammasome activation is responsible for the programmed cell death pytoptosis and cytokine production including IL-1 beta and IL-18. Based on our results, it was clarified that AIM2, type I IFN and kinase signals such as Syk are involved in the inflammasome activation induced by Listeria monocytogenes. Furthermore, we narrowed down the responsible region of listeriolysin O for inflammasome activation as a bacterial factor and revealed that the amino acid region from 204 to 254 of listeriolysin O is important for the activity.
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