| Project/Area Number |
22790407
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Shimane University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | マクロファージ / アポトーシス / 細菌 / シグナル伝達 / 殺菌エフェクター |
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| Research Abstract |
In this study, we examined the correlation between apoptotic signaling pathways and macrophage activities against Mycobaccterium smegmatis(SM) infection. Treatment with 5 mM ATP or 50μM 1-(3, 4-Dichlorobenzyl)-1H-indole-2, 3-dion : Apoptosis activatorII(AAII) induced the apoptosis of macrophages and decreased intramacrophage survival of SM. AAII-induced but not ATP-induced apoptosis recovers in macrophages treated with caspase 3 inhibitor. These results suggest that apoptosis induced by AAIImay be concomitant with the up-regulation of macrophage anti-mycobacterial activities, and this affects a signal transduction involved in caspase 3-mediated apoptosis.
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