Functional analysis of peptidoglycan of Orientia tsutsugamushi.

• Project/Area Number: 22790410
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Bacteriology (including Mycology)
• Research Institution: University of Miyazaki
• Principal Investigator: NAKAYAMA Keisuke 宮崎大学, 医学部, 医員 (10347057)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 微生物 / 細菌 / 遺伝子

Research Abstract

Fosfomycin showed curative effect of the Tsutsugamishi disease in a mouse infection model. It was thought that fosfomycin was also useful for treatment of the Tsutsugamushi disease in humans as a concomitant or/and alternative agent.

Research Products

• [Journal Article] Genome Comparison and Phylogenetic Analysis of Orientia tsutsugamushi Strains (2010)
  • Author(s): K. Nakayama
  • Journal Title: DNA Research Volume: 17 Pages: 281-291
  • Peer Reviewed
• [Journal Article] Genome Comparison and Phylogenetic Analysis of Orientia tsutsugamushi Strains. (2010)
  • Author(s): K.Nakayama, et al.
  • Journal Title: DNA Res. Volume: 17 Pages: 281-291
  • Peer Reviewed
• [Presentation] R. heilongjiangensisのゲノム解析・O. tsutsugamushi新規分離株のMSL解析 (2011)
  • Author(s): 中山恵介・林哲也
  • Organizer: 第3回日本リケッチア症臨床研究会・第17回リケッチア研究会合同研究発表会
  • Place of Presentation: 大津市
  • Year and Date: 2011-01-15
• [Presentation] R.heilongjiangensisのゲノム解析,O.tsutsugamushi新規分離株のMSL解析 (2011)
  • Author(s): 中山恵介、林哲也
  • Organizer: 第3回日本リケッチア症臨床研究会・第17回リケッチア研究会合同研究発表会
  • Place of Presentation: 大津市
  • Year and Date: 2011-01-15
• [Presentation] 細胞壁合成阻害剤オリエンチアの増殖に与える影響 (2010)
  • Author(s): 中山恵介
  • Organizer: 第18回ダニと疾患のインタフェースに関するセミナー
  • Place of Presentation: 佐渡市
  • Year and Date: 2010-06-13
• [Book] 改訂版人獣共通感染症 (2011)
  • Author(s): 中山恵介
  • Publisher: 医薬ジャーナル社