Development of a mouse model of the infection with Streptococcus dysgalactiae subspecies equisimilis.
| Project/Area Number |
22790412
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Kitasato University |
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Principal Investigator |
YOSHIDA Haruno 北里大学, その他の研究科, 助手 (70563386)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Takashi 北里大学, 感染制御科学府, 教授 (00292855)
MATSUI Hidenori 北里大学, 感染制御科学府, 講師 (30219373)
MURAYAMA Somay (YAMAGATA Somay) 日本大学, 薬学部薬学科, 准教授 (60183654)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,899,459 (Direct Cost: ¥3,768,815、Indirect Cost: ¥1,130,644)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,129,459 (Direct Cost: ¥868,815、Indirect Cost: ¥260,644)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | レンサ球菌 / 劇症型感染症 / SDSE / 感染モデル動物 / G群レンサ球菌 / 劇症型 / マウスモデル / ゲノム解析 / A群レンサ球菌 / CD46 / トランスジェニック |
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| Research Abstract |
Ankle arthritis was induced by a single subcutaneous infection od the Streptococcus dysgalactiae subspecies equisimilis strain RE378, which was isolated from a patient suffering from multiple organ failure due to septicaemia, into both hind footpads of human CD46-expressing transgenic(Tg) mice. The histopathological findings in the hind ankle sections of CD46 Tg mice showed the stimulation of osteoclast formation associated with inflammation of the synovial membrane. The comparative genome sequence analysis revealed that the 43 predicted virulence-related factors including putative adhesion proteins and nucleases.
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Report
(5 results)
Research Products
(20 results)
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[Journal Article] A CD46 transgenic mouse model for studying the histopathology of arthritis caused by subcutaneous infection with Streptococcus dysgalactiae subspecies equisimilis2012
Author(s)
Yoshida, H., Matsui, H.Murayama, S.Y., Takada, Y., Matsuo, K.Takahashi, T., Nakamura, M., Ubukata, K., Takahashi, T.
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Journal Title
J.Med.Microb.
Volume: 60
Issue: 12
Pages: 1860-1868
DOI
Related Report
Peer Reviewed
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[Journal Article] Darmal mast cells reduce progressive tissue necrosis caused by subcutaneous infection with Streptococcus pyogenes in mice2011
Author(s)
Hidenori Matsui, Yukie Sekiya, Tetsufumi Takahashi, Masahiko Nakamura, Ken'ichi Imanishi, Haruno Yoshida, Somay Yamagata Murayama, Takashi Takahashi, Kanji Tsuchimoto, Takehiko Uchiyama, and Kimiko Ubukata
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Journal Title
Journal of Medical Microbiology
Volume: 60巻
Issue: 1
Pages: 128-134
DOI
Related Report
Peer Reviewed
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[Journal Article] Darmal mast cells reduce progressive tissue necrosis caused by subcutaneous infection with Streptococcus pyogenes in mice.2011
Author(s)
Hidenori Matsui, Yukie Sekiya, Tetsufumi Takahashi, Masahiko Nakamura, Ken'ichi Imanishi, Haruno Yoshida, Somay Yamagata Murayama, Takashi Takahashi, Kanji Tsuchimoto, Takehiko Uchiyama, Kimiko Ubukata.
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Journal Title
Journal of Medical Microbiology
Volume: 60
Pages: 128-134
Related Report
Peer Reviewed
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[Presentation] CD46 transgenic mouse model of acute severe invasive infections caused by Streptococcus pyogenes2011
Author(s)
Hidenori Matsui, Haruno Yoshida, Somay Y Murayama, Asako Takizawa, Osamu Takeuchi, Tetsufumi Takahashi, Masahiko Nakamura, Ken'Ichi Imanishi, Takehiko Uchiyama, Takashi Takahashi, and Kimiko Ubukata
Organizer
International Union of Microbiological Societies 2011
Place of Presentation
札幌コンベンションセンター(北海道)
Year and Date
2011-07-09
Related Report
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