| Project/Area Number |
22790415
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | サルモネラ / 腸炎 / III型分泌機構 / 3型分泌機構 |
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| Research Abstract |
Salmonella enterica serovar Typhimurium causes acute gastroenteritis. This bacterium has three Type III secretion systems(SPI-1, SPI-2 and flagella), which are required for intestinal inflammation. In this study, we tried to identify effectors secreted into host cells through T3SS-2.Unfortunately, we could not identify the SPI-2 effector associated with acute intestinal inflammation in a streptomycin pretreated mouse model. However, we showed that SpvC, both SPI-1 and SPI-2 T3SS effector, evades the immune response in the intestinal mucosa in the early stage of infection and facilitates bacterial dissemination at late stages of infection.
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