| Project/Area Number |
22790416
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 敗血症 / alarmin / 感染免疫 / リポ多糖(LPS) / HMGN1 / Alarmin |
|---|
| Research Abstract |
HMGN1, a non-histon chromosomal protein, induces the recruitment of dendritic cells into the sites of HMGN1 administration, and enhances the antigen-specific immune responses. Thus, HMGN1 is estimated to act as an alarmin, when released in the extracellular milieu. In this study, we elucidated the mechanism of HMGN1 release from mouse macrophage RAW cells by LPS stimulation. HMGN1 release was accompanied with cell death which is not affected by Ac-YVAD-CHO, a specific inhibitor of caspase-1. Together these observations indicate that HMGN1 release is accompanied with the LPS-induced cell death, which is independent of caspase-1 activation.
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