• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Study on the molecular mechanisms of host adaptation of Leptospira interrogans

Research Project

Project/Area Number 22790422
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Bacteriology (including Mycology)
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

KOIZUMI Nobuo  国立感染症研究所, 細菌第一部, 主任研究官 (10333361)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords病原性 / 人獣共通感染症 / レプトスピラ / スピロヘータ
Research Abstract

To identify leptospiral proteins which function in cell attachment, we employed recombinant T7 phage and Escherichia coli which expresses leptospiral proteins fused with 10B capsid protein and AIDA transporter protein on its cell surface, respectively. We screened recombinant phages and E coli cells which bound to cultured cells but failed to obtain specific clones. We established a method of mariner transposon mediated mutagenesis in pathogenic and non-pathogenic Leptospira spp by conjugational transfer with E coli.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (3 results)

All 2013 2012

All Journal Article (2 results) Presentation (1 results)

  • [Journal Article] レプトスピラ症の現状2013

    • Author(s)
      小泉信夫
    • Journal Title

      獣医畜産新報

      Volume: 66巻 Pages: 252-254

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] レプトスピラ症2013

    • Author(s)
      小泉信夫
    • Journal Title

      化学療法の領域

      Volume: 29巻 Pages: 670-678

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] レプトスピラ症の現状2012

    • Author(s)
      小泉信夫
    • Organizer
      第12回人と動物の共通感染症研究会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2012-11-03
    • Related Report
      2012 Annual Research Report 2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi