Molecular characterization of novel isoniazid resistance mechanism in Mycobacterium tuberculosis
| Project/Area Number |
22790423
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
ANDO Hiroki 独立行政法人国立国際医療研究センター, 感染症制御研究部, 上級研究員 (70462786)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 結核 / 薬剤耐性 / イソニアジド |
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| Research Abstract |
Novel isoniazid (INH) resistance mutations were identified and characterized in Mycobacterium tuberculosis (Mtb). I collected INH-resistant Mtb clinical isolates and found that many of them have no mutations in known INH resistance genes. I identified several novel mutations in these isolates, and analyzed their roles in INH resistance.
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Report
(3 results)
Research Products
(15 results)
