Analysis of mechanism of latent infection and reactivation of varicella-zoster virus
| Project/Area Number |
22790428
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | University of Toyama |
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Principal Investigator |
TAKEMOTO Masaya 富山大学, 大学院・医学薬学研究部(医学), 助教 (60379237)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 抗原変調AV3(antigenic modulation) / shedding microvesicles / オートファジー / 水痘帯状疱疹ウイルス / glycoprotein H / glycoprotein H (gH) / 小胞体ストレス |
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| Research Abstract |
Monoclonal antibody against glycoprotein H(gH) encoded by varicella-zoster virus(VZV) terminates lytic replication of VZV and induces the quiescently infected cells with dormant but recoverable VZV infectivity. It was demonstrated that autophagic clearance of intracellular gH and shedding microvesicle-mediated VZV virion outside the infected cells.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Efficacy of ASP2151, a helicase-primase inhibitor, against thymidine kinase-deficient herpes simplex virus type 2 infection in vitro and in vivo2012
Author(s)
Takehiro Himaki, Yumi Masui, Koji Chono, Tohru Daikoku, Masaya Takemoto, Bo Haixia, Tomoko Okuda, Hiroshi Suzuki, Kimiyasu Shiraki
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Journal Title
Antiviral Research
Volume: 93-2
Pages: 301-4
Related Report
Peer Reviewed
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[Journal Article] Efficacy of ASP2151, a helicase-primase inhibitor, against thymidine kinase-deficient herpes simplex virus type 2 infection in vitro and in vivo.2012
Author(s)
Himaki T, Masui Y, Chono K, Daikoku T, Takemoto M, Haixia B, Okuda T, Suzuki H, Shiraki K.
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Journal Title
Antiviral Research.
Volume: 93(2)
Issue: 2
Pages: 301-304
DOI
Related Report
Peer Reviewed
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