Development of a new nasal vaccine effective against many types of influenza that based on pulmonary surfactant
| Project/Area Number |
22790433
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MIZUNO Dai 徳島大学, 疾患酵素学研究センター, 助教 (70380061)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 感染防御 / ワクチン / 肺サーファクタント / 経鼻ワクチン / インフルエンザ / ペプチドワクチン |
|---|
| Research Abstract |
We developed a new vaccine, which was constitute of influeza M2 angigen and SF10 a synthetic adjuvant that mimics pulmonary surfactant. Fluoresceinated M2 delivery to cultured dendritic cells was significantly enhanced by co-administration of SF10. And intranasal immunization of M2-SF10 enhanced local and systemic immune responses, compared with those induced by M2 antigen alone.
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Report
(3 results)
Research Products
(25 results)
