Elucidation of molecular mechanisms HIV viral latency and its reactivation involving epigenetic regulation
| Project/Area Number |
22790437
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | Nihon University |
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Principal Investigator |
IMAI Kenichi 日本大学, 歯学部, 准教授 (60381810)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | HIV/AIDS / 潜伏感染 / 酪酸 / G9a / HDAC / エピジェネティクス / ヒストン / HIV / HDA / 転写 / エピジェネティック / メチル化 |
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| Research Abstract |
Elucidation of the molecular mechanisms involved in the maintenance and breakdown of HIV latency is required for a comprehensive understanding of the pathophysiology of HIV-1 infection and the development of novel therapies. We have examined that epigenetic regulation is involved in the establishment and maintenance of HIV-1 latency and in the reactivation of HIV-1 by butyric acid-producing bacteria.
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Report
(3 results)
Research Products
(33 results)
