Visualization of influenza virus progeny vRNP complex and analysis of cytoplasmic machineries responsible for polarized vRNP trafficking.
| Project/Area Number |
22790438
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | Kitasato University |
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Principal Investigator |
MOMOSE Fumitaka 北里大学, 大学院・感染制御科学府, 講師 (90332204)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | インフルエンザウイルス / 微小管 / 宿主因子 / モノクローナル抗体 / ライブセルイメージング / 低分子量GTP結合タンパク質 / リサイクリングエンドソーム / RNP複合体 / タンパク質導入 / 微小管輸送 / 極性輸送 |
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| Research Abstract |
This study revealed that Rab11-positive recycling endosomes(RE) participate in the polarized trafficking of influenza A virus ribonucleoprotein complexes(vRNP) to the apical plasma membrane. The targeting of vRNP to the RE depends on the specific interaction between viral RNA dependent RNA polymerase on vRNP and GTP-bound active Rab11.This RE dependent apical transport of vRNP also requires class II Rab11 effector proteins such as Rab11-FIP3/4.
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Report
(3 results)
Research Products
(21 results)
