Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Research Abstract |
Epstein-Barr(EB) virus is a causative agent of serious diseases, including infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal cancer, or gastric cancer. Changes of viral lifecycles, such as reactivation from latency, have been implicated in the severity or state of the diseases, and thus analyzing mechanisms of such transitions is of importance. We here newly identified transcription factors that regulate the virus reactivation, and observed epigenetic alterations mediated by those factors(Murata et al., JBC 2010, 2011, Murata et al., JV 2012).
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