In vivo role of novel innate immune factors during viral infection
| Project/Area Number |
22790450
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 自然免疫 / ウイルス / インターフェロン / 核酸 / ユビキチン / インフルエンザ / C型肝炎 / シグナル / RIG-I / I型インターフェロン / Riplet / 免疫 / 炎症 |
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| Research Abstract |
Innate immune response is essential for the protection against viral infection, such as novel flu or Hepatitis C virus. We have previously isolated a novel protein, Riplet. We constructed Riplet deficient mice and examined its phenotype. We found that Riplet is essential for type I interferon production, which possesses strong antiviral activity, in response to viral infection in vivo.
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Report
(3 results)
Research Products
(20 results)
