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Regulation of memory CD4 T cell pool size and function by NKT cells

Research Project

Project/Area Number 22790452
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionChiba University

Principal Investigator

IWAMURA Chiaki  千葉大学, 大学院・医学研究院, 助教 (10513062)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsアレルギー / 免疫関連疾患 / 免疫記憶 / NKT細胞
Research Abstract

Activation of NKT cells with glycolipid ligands induced a dramatic proliferation and expansion of memory CD4 T cells. Type II NKT cells were also required for efficient maintenance of memory CD4 T cells in vivo. Activation of iNKT cells resulted in decreased capability to induce Th2 cytokines and eosinophilic airway inflammation. Thus, activated NKT cells directly regulate memory CD4 T cell pool size and function via the production of cytokines in vivo.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (31 results)

All 2012 2011 2010 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (17 results)

  • [Journal Article] Murine Schnurri-2 controls Natural Killer cell function and lymphoma development2012

    • Author(s)
      Yamashita, J., Iwamura, C., Mitsumori, K., Hosokawa, H., Sasaki, T., Takahashi, M., Tanaka, H., Kaneko, K., Hanazawa, A., Watanabe, Y., Shinoda, K., Tumes, D., Motohashi, S., Nakayama, T.
    • Journal Title

      Leuk.Lymphoma

      Volume: 53 Issue: 3 Pages: 479-486

    • DOI

      10.3109/10428194.2011.625099

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cigarette smoke-induced pulmonary inflammation is attenuated in CD69-deficient mice2011

    • Author(s)
      Tsuyusaki, J., Kuroda, F., Kasuya, Y., Ishizaki, I., Yamauchi, K., Sugimoto, H., Kono, T., Iwamura, C., Nakayama, T., Tatsumi, K.
    • Journal Title

      J.Recept.Sig.Transduct.Res.

      Volume: 31 Issue: 6 Pages: 434-439

    • DOI

      10.3109/10799893.2011.631929

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA32011

    • Author(s)
      Endo, Y., Iwamura, C., Kuwahara, M., Suzuki, A., Sugaya, K., Tumes, J. D., Tokoyoda, K. Hosokawa, H., Yamashita, M. Nakayama, T
    • Journal Title

      Immunity

      Volume: 35 Issue: 5 Pages: 733-745

    • DOI

      10.1016/j.immuni.2011.08.017

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin2011

    • Author(s)
      Yamauchi, K., Kasuya, Y., Kuroda, F., Tanaka, K., Tsuyusaki, J., Ishizaki, S., Matsunaga, H., Iwamura, C., Nakayama, T. Tatsumi, K
    • Journal Title

      Respir. Res

      Volume: 12 Issue: 1 Pages: 131-131

    • DOI

      10.1186/1465-9921-12-131

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Repressor of GATA negatively regulates murine contact hypersensitivity through the inhibition of type-2 allergic responses2011

    • Author(s)
      Hirasaki, Y., Iwamura, C., Yamashita, M., Ito, T., Kitajima, M., Shinoda, K., Namiki, T., Terasawa, K. Nakayama, T
    • Journal Title

      Clin. Immunol

      Volume: 139 Issue: 3 Pages: 267-276

    • DOI

      10.1016/j.clim.2011.02.009

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Apolipoprotein A-II suppressed concanavalin A-induced hepatitis via the inhibition of CD4 T cell function2011

    • Author(s)
      Yamashita, J., Iwamura, C., Sasaki, T., Mitsumori, K., Ohshima, K., Hada, K., Hara, N., Takahashi, M., Kaneshiro, Y., Tanaka, H., Kaneko, K. Nakayama, T
    • Journal Title

      J. Immunol

      Volume: 186 Issue: 6 Pages: 3410-3420

    • DOI

      10.4049/jimmunol.1002924

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ncrease of regulatory T cells and the ratio of specific IgE to total IgE are candidates for response monitoring or prognostic biomarkers in 2-year sublingual immunotherapy (SLIT) for Japanese cedar pollinosis2011

    • Author(s)
      Fujimura, T., Yonekura, S., Horiguchi, S., Taniguchi, Y., Saito, A., Yasueda, H., Inamine, A., Nakayama, T., Takemori, T., Taniguchi, M., Sakaguchi, M. Okamoto, Y
    • Journal Title

      Clin. Immunol

      Volume: 139 Issue: 1 Pages: 65-74

    • DOI

      10.1016/j.clim.2010.12.022

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Repressor of GATA negatively regulates murine contact hypersensitivity through the inhibition of type-2 allergic responses.2011

    • Author(s)
      Hirasaki, Y.
    • Journal Title

      Clin.Immunol

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apolipoprotein A-II Suppressed Concanavalin A-Induced Hepatitis via the Inhibition of CD4 T Cell Function.2011

    • Author(s)
      Yamashita, J.
    • Journal Title

      J.Immunol

      Volume: 186 Pages: 3410-20

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of NKT cells in allergic asthma. Curr2010

    • Author(s)
      Iwamura, C. Nakayama, T
    • Journal Title

      Opin. Immunol

      Volume: 22 Issue: 6 Pages: 807-81

    • DOI

      10.1016/j.coi.2010.10.008

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung2010

    • Author(s)
      Suzuki, A., Iwamura, C., Shinoda, K., Tumes, J. D., Kimura, Y. M., Hosokawa, H., Endo, Y., Horiuchi, S., Tokoyoda, K., Koseki, H., Yamashita, M. Nakayama, T
    • Journal Title

      J. Immunol

      Volume: 184 Issue: 8 Pages: 4510-4520

    • DOI

      10.4049/jimmunol.0903426

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Naringenin Chalcone Suppresses Allergic Asthma by Inhibiting the Type-2 Function of CD4 T Cells2010

    • Author(s)
      Iwamura, C., Shinoda, K., Yoshimura, M., Watanabe, Y., Obata, A. Nakayama, T
    • Journal Title

      Allergology International

      Volume: 59 Issue: 1 Pages: 67-73

    • DOI

      10.2332/allergolint.09-OA-0118

    • NAID

      130004477071

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of NKT cells in allergic asthma.2010

    • Author(s)
      Iwamura, C.
    • Journal Title

      Curr Opin Immunol

      Volume: 22 Pages: 807-13

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of CD69 in acute lung injury

    • Author(s)
      Ishizaki S, Kasuya Y, Kuroda F, Tanaka K, Tsuyusaki J, Yamauchi K, Mastsunaga H, Iwamura C, Nakayama T., Tatsumi K.
    • Journal Title

      Life Sciences

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] VILI (Ventilator-Induced Lung Injury)modelにおけるNKT細胞の関与と役割/Protective role of NKT cells against ventilator-induced lung injury2011

    • Author(s)
      志賀由佳, 菅又龍一, 長尾朋和, 岩村千秋, 川上和義, 河内正治, 中山俊憲, 鈴木和男
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-29
    • Related Report
      2011 Final Research Report
  • [Presentation] VILI (Ventilator-Induced Lung Injury) modelにおけるNKT細胞の関与と役割/Protective role of NKT cells against ventilator-induced lung injury2011

    • Author(s)
      志賀由佳、菅又龍一、長尾朋和、岩村千秋、川上和義、河内正治、中山俊憲、鈴木和男
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウスSchnurri-2 はNK細胞の機能とリンパ腫の発症を制御する/ Murine Schnurri-2 controls Natural Killer cell function and lymphomadevelopment2011

    • Author(s)
      Yamashita, J., Iwamura, C., Hosokawa, H., Sasaki, T., Tumes, D., Motohashi, S., Nakayama, T
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 活性化NKT細胞によるメモリ-Th2細胞の増加と機能変化/ Selective expansion and functional modulation of memory Th2 cells by activated NKT cells in vivo2011

    • Author(s)
      岩村千秋, 篠田健太, 高橋克己, 中山俊憲
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-28
    • Related Report
      2011 Final Research Report
  • [Presentation] マウスSchnurri-2はNK細胞の機能とリンパ腫の発症を制御する/Murine Schnurri-2 controls Natural Killer cell function and lymphoma development2011

    • Author(s)
      Yamashita, J., Iwamura, C., Hosokawa, H., Sasaki, T., Tumes, D., Motohashi, S., Nakayama, T
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 活性化NKT細胞によるメモリーTh2細胞の増加と機能変化/Selective expansion and functional modulation of memory Th2 cells by activated NKT cells in vivo2011

    • Author(s)
      岩村千秋、篠田健太、高橋克己、中山俊憲
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Sox4 はTGFβにより誘導され、Th2型免疫反応を抑制する/Sox4 acts as a downstream target of TGFβ and suppresses Th2 type immune responses2011

    • Author(s)
      Kuwahara, M., Iwamura, C., Shinoda, K., Tofukuji, S., Suzuki, J., Nakayama, T., Yamashita, M
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-27
    • Related Report
      2011 Final Research Report
  • [Presentation] ROG はTh2 による肥満細胞の脱顆粒を制御する事で接触性皮膚炎を抑制する/Repressor of GATA negatively regulates the induction of contact hypersensitivity via Th2-induced mast cell degranulation2011

    • Author(s)
      Hirasaki, Y., Iwamura, C., Yamashita, M., Ito, T., Shinoda, K., Nakayama,T
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Sox4はTGFbにより誘導され、Th2型免疫反応を抑制する/Sox4 acts as a downstream target of TGFb and suppresses Th2 type immune responses2011

    • Author(s)
      Kuwahara, M., Iwamura, C, Shinoda, K., Tofukuji, S., Suzuki, J., Nakayama, T., Yamashita, M.
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] ROGはTh2による肥満細胞の脱顆粒を制御する事で接触性皮膚炎を抑制する/Repressor of GATA negatively regulates the induction of contact hypersensitivity via Th2-induced mast cell degranulation2011

    • Author(s)
      Hirasaki, Y., Iwamura, C., Yamashita, M., Ito, T., Shinoda, K., Nakayama, T
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] NKT cell-mediated regulation of antigen-specific memory Th2 cell function2011

    • Author(s)
      Nakayama, T., Iwamura, C
    • Organizer
      6th International Symposium on CD1 and NKT Cells
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2011-09-25
    • Related Report
      2011 Final Research Report
  • [Presentation] HMG box型転写因子Sox4はTGF-b刺激で誘導され、Th2細胞分化を抑制する2011

    • Author(s)
      桑原誠, 岩村千秋, 篠田健太, 東福寺聡一, 鈴木淳平, 中山俊憲, 山下政克
    • Organizer
      第21回Kyoto T Cell Conference
    • Place of Presentation
      京都
    • Year and Date
      2011-06-11
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Selective expansion and functional modulation of memory Th2 cells by activated NKT cells in vivo2011

    • Author(s)
      岩村千秋, 篠田健太, 花澤麻美, 中山俊憲
    • Organizer
      第21回Kyoto T Cell Conference
    • Place of Presentation
      京都
    • Year and Date
      2011-06-11
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] CD69 controls the pathogenesis of allergic airway inflammation2010

    • Author(s)
      Iwamura, C., Hosokawa, H., Hasegawa, A., Nakayama, T
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe
    • Year and Date
      2010-08-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 活性化NKT細胞によるメモリーCD4T細胞の数と機能の制御2010

    • Author(s)
      岩村千秋
    • Organizer
      第14回国際免疫学会議
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Year and Date
      2010-08-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 活性化NKT細胞によるメモリーCD4T細胞の数と機能の制御2010

    • Author(s)
      岩村千秋
    • Organizer
      第20回Kyoto T Cell Conference
    • Place of Presentation
      京都
    • Year and Date
      2010-06-05
    • Related Report
      2011 Final Research Report
  • [Presentation] 活性化NKT細胞によるメモリーCD4T細胞の数と機能の制御2010

    • Author(s)
      岩村千秋
    • Organizer
      第20回Kyoto T Cell Conference
    • Place of Presentation
      京都大学芝蘭会館(京都府)
    • Year and Date
      2010-06-05
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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