Regulation of memory CD4 T cell pool size and function by NKT cells

• Project/Area Number: 22790452
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Chiba University
• Principal Investigator: IWAMURA Chiaki 千葉大学, 大学院・医学研究院, 助教 (10513062)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: アレルギー / 免疫関連疾患 / 免疫記憶 / NKT細胞

Research Abstract

Activation of NKT cells with glycolipid ligands induced a dramatic proliferation and expansion of memory CD4 T cells. Type II NKT cells were also required for efficient maintenance of memory CD4 T cells in vivo. Activation of iNKT cells resulted in decreased capability to induce Th2 cytokines and eosinophilic airway inflammation. Thus, activated NKT cells directly regulate memory CD4 T cell pool size and function via the production of cytokines in vivo.

Research Products

• [Journal Article] Murine Schnurri-2 controls Natural Killer cell function and lymphoma development (2012)
  • Author(s): Yamashita, J., Iwamura, C., Mitsumori, K., Hosokawa, H., Sasaki, T., Takahashi, M., Tanaka, H., Kaneko, K., Hanazawa, A., Watanabe, Y., Shinoda, K., Tumes, D., Motohashi, S., Nakayama, T.
  • Journal Title: Leuk.Lymphoma Volume: 53 Issue: 3 Pages: 479-486
  • DOI: 10.3109/10428194.2011.625099
  • Peer Reviewed
• [Journal Article] Cigarette smoke-induced pulmonary inflammation is attenuated in CD69-deficient mice (2011)
  • Author(s): Tsuyusaki, J., Kuroda, F., Kasuya, Y., Ishizaki, I., Yamauchi, K., Sugimoto, H., Kono, T., Iwamura, C., Nakayama, T., Tatsumi, K.
  • Journal Title: J.Recept.Sig.Transduct.Res. Volume: 31 Issue: 6 Pages: 434-439
  • DOI: 10.3109/10799893.2011.631929
  • Peer Reviewed
• [Journal Article] Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3 (2011)
  • Author(s): Endo, Y., Iwamura, C., Kuwahara, M., Suzuki, A., Sugaya, K., Tumes, J. D., Tokoyoda, K. Hosokawa, H., Yamashita, M. Nakayama, T
  • Journal Title: Immunity Volume: 35 Issue: 5 Pages: 733-745
  • DOI: 10.1016/j.immuni.2011.08.017
  • Peer Reviewed
• [Journal Article] Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin (2011)
  • Author(s): Yamauchi, K., Kasuya, Y., Kuroda, F., Tanaka, K., Tsuyusaki, J., Ishizaki, S., Matsunaga, H., Iwamura, C., Nakayama, T. Tatsumi, K
  • Journal Title: Respir. Res Volume: 12 Issue: 1 Pages: 131-131
  • DOI: 10.1186/1465-9921-12-131
  • Peer Reviewed
• [Journal Article] Repressor of GATA negatively regulates murine contact hypersensitivity through the inhibition of type-2 allergic responses (2011)
  • Author(s): Hirasaki, Y., Iwamura, C., Yamashita, M., Ito, T., Kitajima, M., Shinoda, K., Namiki, T., Terasawa, K. Nakayama, T
  • Journal Title: Clin. Immunol Volume: 139 Issue: 3 Pages: 267-276
  • DOI: 10.1016/j.clim.2011.02.009
  • Peer Reviewed
• [Journal Article] Apolipoprotein A-II suppressed concanavalin A-induced hepatitis via the inhibition of CD4 T cell function (2011)
  • Author(s): Yamashita, J., Iwamura, C., Sasaki, T., Mitsumori, K., Ohshima, K., Hada, K., Hara, N., Takahashi, M., Kaneshiro, Y., Tanaka, H., Kaneko, K. Nakayama, T
  • Journal Title: J. Immunol Volume: 186 Issue: 6 Pages: 3410-3420
  • DOI: 10.4049/jimmunol.1002924
  • Peer Reviewed
• [Journal Article] ncrease of regulatory T cells and the ratio of specific IgE to total IgE are candidates for response monitoring or prognostic biomarkers in 2-year sublingual immunotherapy (SLIT) for Japanese cedar pollinosis (2011)
  • Author(s): Fujimura, T., Yonekura, S., Horiguchi, S., Taniguchi, Y., Saito, A., Yasueda, H., Inamine, A., Nakayama, T., Takemori, T., Taniguchi, M., Sakaguchi, M. Okamoto, Y
  • Journal Title: Clin. Immunol Volume: 139 Issue: 1 Pages: 65-74
  • DOI: 10.1016/j.clim.2010.12.022
  • Peer Reviewed
• [Journal Article] Repressor of GATA negatively regulates murine contact hypersensitivity through the inhibition of type-2 allergic responses. (2011)
  • Author(s): Hirasaki, Y.
  • Journal Title: Clin.Immunol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Apolipoprotein A-II Suppressed Concanavalin A-Induced Hepatitis via the Inhibition of CD4 T Cell Function. (2011)
  • Author(s): Yamashita, J.
  • Journal Title: J.Immunol Volume: 186 Pages: 3410-20
  • Peer Reviewed
• [Journal Article] Role of NKT cells in allergic asthma. Curr (2010)
  • Author(s): Iwamura, C. Nakayama, T
  • Journal Title: Opin. Immunol Volume: 22 Issue: 6 Pages: 807-81
  • DOI: 10.1016/j.coi.2010.10.008
  • Peer Reviewed
• [Journal Article] Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung (2010)
  • Author(s): Suzuki, A., Iwamura, C., Shinoda, K., Tumes, J. D., Kimura, Y. M., Hosokawa, H., Endo, Y., Horiuchi, S., Tokoyoda, K., Koseki, H., Yamashita, M. Nakayama, T
  • Journal Title: J. Immunol Volume: 184 Issue: 8 Pages: 4510-4520
  • DOI: 10.4049/jimmunol.0903426
  • Peer Reviewed
• [Journal Article] Naringenin Chalcone Suppresses Allergic Asthma by Inhibiting the Type-2 Function of CD4 T Cells (2010)
  • Author(s): Iwamura, C., Shinoda, K., Yoshimura, M., Watanabe, Y., Obata, A. Nakayama, T
  • Journal Title: Allergology International Volume: 59 Issue: 1 Pages: 67-73
  • DOI: 10.2332/allergolint.09-OA-0118
  • NAID: 130004477071
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Role of NKT cells in allergic asthma. (2010)
  • Author(s): Iwamura, C.
  • Journal Title: Curr Opin Immunol Volume: 22 Pages: 807-13
  • Peer Reviewed
• [Journal Article] Role of CD69 in acute lung injury
  • Author(s): Ishizaki S, Kasuya Y, Kuroda F, Tanaka K, Tsuyusaki J, Yamauchi K, Mastsunaga H, Iwamura C, Nakayama T., Tatsumi K.
  • Journal Title: Life Sciences Volume: (In press)
  • Peer Reviewed
• [Presentation] VILI (Ventilator-Induced Lung Injury)modelにおけるNKT細胞の関与と役割/Protective role of NKT cells against ventilator-induced lung injury (2011)
  • Author(s): 志賀由佳, 菅又龍一, 長尾朋和, 岩村千秋, 川上和義, 河内正治, 中山俊憲, 鈴木和男
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-29
• [Presentation] VILI (Ventilator-Induced Lung Injury) modelにおけるNKT細胞の関与と役割/Protective role of NKT cells against ventilator-induced lung injury (2011)
  • Author(s): 志賀由佳、菅又龍一、長尾朋和、岩村千秋、川上和義、河内正治、中山俊憲、鈴木和男
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-29
• [Presentation] マウスSchnurri-2 はNK細胞の機能とリンパ腫の発症を制御する/ Murine Schnurri-2 controls Natural Killer cell function and lymphomadevelopment (2011)
  • Author(s): Yamashita, J., Iwamura, C., Hosokawa, H., Sasaki, T., Tumes, D., Motohashi, S., Nakayama, T
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] 活性化NKT細胞によるメモリ-Th2細胞の増加と機能変化/ Selective expansion and functional modulation of memory Th2 cells by activated NKT cells in vivo (2011)
  • Author(s): 岩村千秋, 篠田健太, 高橋克己, 中山俊憲
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] マウスSchnurri-2はNK細胞の機能とリンパ腫の発症を制御する/Murine Schnurri-2 controls Natural Killer cell function and lymphoma development (2011)
  • Author(s): Yamashita, J., Iwamura, C., Hosokawa, H., Sasaki, T., Tumes, D., Motohashi, S., Nakayama, T
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] 活性化NKT細胞によるメモリーTh2細胞の増加と機能変化/Selective expansion and functional modulation of memory Th2 cells by activated NKT cells in vivo (2011)
  • Author(s): 岩村千秋、篠田健太、高橋克己、中山俊憲
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] Sox4 はTGFβにより誘導され、Th2型免疫反応を抑制する/Sox4 acts as a downstream target of TGFβ and suppresses Th2 type immune responses (2011)
  • Author(s): Kuwahara, M., Iwamura, C., Shinoda, K., Tofukuji, S., Suzuki, J., Nakayama, T., Yamashita, M
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] ROG はTh2 による肥満細胞の脱顆粒を制御する事で接触性皮膚炎を抑制する/Repressor of GATA negatively regulates the induction of contact hypersensitivity via Th2-induced mast cell degranulation (2011)
  • Author(s): Hirasaki, Y., Iwamura, C., Yamashita, M., Ito, T., Shinoda, K., Nakayama,T
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] Sox4はTGFbにより誘導され、Th2型免疫反応を抑制する/Sox4 acts as a downstream target of TGFb and suppresses Th2 type immune responses (2011)
  • Author(s): Kuwahara, M., Iwamura, C, Shinoda, K., Tofukuji, S., Suzuki, J., Nakayama, T., Yamashita, M.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] ROGはTh2による肥満細胞の脱顆粒を制御する事で接触性皮膚炎を抑制する/Repressor of GATA negatively regulates the induction of contact hypersensitivity via Th2-induced mast cell degranulation (2011)
  • Author(s): Hirasaki, Y., Iwamura, C., Yamashita, M., Ito, T., Shinoda, K., Nakayama, T
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] NKT cell-mediated regulation of antigen-specific memory Th2 cell function (2011)
  • Author(s): Nakayama, T., Iwamura, C
  • Organizer: 6th International Symposium on CD1 and NKT Cells
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-09-25
• [Presentation] HMG box型転写因子Sox4はTGF-b刺激で誘導され、Th2細胞分化を抑制する (2011)
  • Author(s): 桑原誠, 岩村千秋, 篠田健太, 東福寺聡一, 鈴木淳平, 中山俊憲, 山下政克
  • Organizer: 第21回Kyoto T Cell Conference
  • Place of Presentation: 京都
  • Year and Date: 2011-06-11
• [Presentation] Selective expansion and functional modulation of memory Th2 cells by activated NKT cells in vivo (2011)
  • Author(s): 岩村千秋, 篠田健太, 花澤麻美, 中山俊憲
  • Organizer: 第21回Kyoto T Cell Conference
  • Place of Presentation: 京都
  • Year and Date: 2011-06-11
• [Presentation] CD69 controls the pathogenesis of allergic airway inflammation (2010)
  • Author(s): Iwamura, C., Hosokawa, H., Hasegawa, A., Nakayama, T
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe
  • Year and Date: 2010-08-26
• [Presentation] 活性化NKT細胞によるメモリーCD4T細胞の数と機能の制御 (2010)
  • Author(s): 岩村千秋
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸ポートピアホテル(兵庫県)
  • Year and Date: 2010-08-26
• [Presentation] 活性化NKT細胞によるメモリーCD4T細胞の数と機能の制御 (2010)
  • Author(s): 岩村千秋
  • Organizer: 第20回Kyoto T Cell Conference
  • Place of Presentation: 京都
  • Year and Date: 2010-06-05
• [Presentation] 活性化NKT細胞によるメモリーCD4T細胞の数と機能の制御 (2010)
  • Author(s): 岩村千秋
  • Organizer: 第20回Kyoto T Cell Conference
  • Place of Presentation: 京都大学芝蘭会館(京都府)
  • Year and Date: 2010-06-05