Role of chemokine receptor CXCR3 on generation and maintenance of memory CD8 T cells

• Project/Area Number: 22790453
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: The University of Tokyo
• Principal Investigator: KURACHI Makoto 東京大学, 大学院・医学系研究科, 助教 (00396722)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 免疫記憶 / CD8陽性T細胞 / CXCR3 / エフェクター分化 / 脾臓辺縁帯 / 抗原特異的CD8陽性T細胞 / メモリー細胞 / ワクチン / ウイルス免疫

Research Abstract

It is not known how early lymphocyte distribution after infection has an impact on this process. We demonstrate that the chemokine receptor CXCR3 is involved in promoting CD8^+T cell commitment to an effector fate rather than a memory fate by regulating T cell recruitment to an antigen/inflammation site.

Research Products

• [Journal Article] Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration (2011)
  • Author(s): Kurachi Makoto
  • Journal Title: The Journal of Experimental Medicine Volume: 208 Issue: 8 Pages: 1605-1620
  • DOI: 10.1084/jem.20102101
  • Peer Reviewed
• [Presentation] Chemokine receptor CXCR3 facilitates CD8^+T cell differentiation into short-lived effector cells leading to memory degeneration (2011)
  • Author(s): Kurachi Makoto
  • Organizer: 米国免疫学会(AAI2011)
  • Place of Presentation: アメリカ合衆国サンフランシスコ国際会議場
  • Year and Date: 2011-05-16
• [Presentation] Chemokine receptor CXCR3 facilitates CD8^+ T cell differentiation into short-lived effector cells leading to memory degeneration (2011)
  • Author(s): 倉知慎
  • Organizer: 米国免疫学会(AAI2011)
  • Place of Presentation: サンフランシスコ国際会議場(アメリカ合衆国)
  • Year and Date: 2011-05-16
• [Presentation] Chemokine receptor CXCR3 facilitates CD8+T cell differentiation into short-lived effector cells leading to memory degeneration (2011)
  • Author(s): Kurachi Makoto
  • Organizer: Keystone Symposium
  • Place of Presentation: Fairmont Hotel(Banff、Canada)
  • Year and Date: 2011-02-08
• [Presentation] Chemokine receptor CXCR3 facilitates CD8+ T cell differentiation into short-lived effector cells leading to memory degeneration (2011)
  • Author(s): Makoto Kurachi
  • Organizer: Keystone Symposium
  • Place of Presentation: Fairmont Hotel (Banff、Canada)
  • Year and Date: 2011-02-08
• [Presentation] Chemokine receptor CXCR3 regulates the generation of memory CTL (2010)
  • Author(s): Kurachi Makoto
  • Organizer: International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2010-08-25
• [Presentation] Chemokine receptor CXCR3 regulates the generation of memory CTL (2010)
  • Author(s): Makoto Kurachi
  • Organizer: International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2010-08-25
• [Presentation] 抗原特異的CD8陽性T細胞(CTL)応答においてケモカイン受容体CXCR3はエフェクターCTLへの分化を促進しメモリーCTL樹立を制御する (2010)
  • Author(s): 倉知慎
  • Organizer: 日本炎症再生医学会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2010-08-05
• [Presentation] 抗原特異的CD8陽性T細胞(CTL)応答においてケモカイン受容体CXCR3はエフェクターCTLへの分化を促進しメモリーCTL樹立を制御する (2010)
  • Author(s): 倉知慎
  • Organizer: 日本炎症再生医学会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2010-08-05
• [Remarks]
  • URL: http://www.prevent.m.u-tokyo.ac.jp/