Key roles of a nuclear IkappaB molecule, IkappaBNS, in the regulation of humoral immunity

• Project/Area Number: 22790457
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Niigata University
• Principal Investigator: TOUMA Maki 新潟大学, 自然科学系, 助教 (40542246)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 獲得免疫 / NF-kappaB / B細胞 / 液性免疫 / 抗体産生

Research Abstract

IκBNS has been identified as a member of the IκB family of NF-κB inhibitors, which is recognized as a regulatory factor of innate immunity. In this study, I found that IκBNS KO B cells are deficient in proliferation, immunoglobulin production and plasma cell differentiation. These results suggest a previously unidentified role for IκBNS in humoral immune regulation.

Research Products

• [Journal Article] Impaired B Cell Development and Function in the Absence of IκBNS. (2011)
  • Author(s): Touma M, Keskin DB, Shiroki F, Saito I, Koyasu S, Reinherz EL, Clayton LK
  • Journal Title: The Journal of Immunology Volume: 187(8) Pages: 3942-52
  • Peer Reviewed
• [Journal Article] Impaired B Cell Development and Function in the Absence of IκBNS (2011)
  • Author(s): Touma M, Keskin DB, Shiroki F, Saito I, Koyasu s, Reinherz EL, Clayton LK
  • Journal Title: The Journal of Immunology Volume: 187 Pages: 3942-52
  • Peer Reviewed
• [Presentation] Bリンパ球の分化・機能発現におけるIκBNSの役割 (2011)
  • Author(s): 齋藤いぶき, 藤間真紀, Linda K.Clayton
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 千葉幕張メッセ
  • Year and Date: 2011-11-28
• [Presentation] メッセ, 2-G-W36-5-O/P口頭,ポスター発表, Bリンパ球の分化・機能発現におけるIκBNSの役割(Impaired differentiation and function of B cells in the absence of IkappaBNS) (2011)
  • Author(s): Ibuki Saito, Maki Touma, Linda K. Clayton
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 千葉幕張
• [Presentation] WS/PP-030-04口頭,ポスター発表, A key role for IκBNS in control of B cell development and function (2010)
  • Author(s): M. Touma, D. B. Keskin, E. L. Reinherz, L. K. Clayton
  • Organizer: 第14回国際免疫学会14th International congress of Immunology
  • Place of Presentation: 神戸国際会議場