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Regulation of IL-7R expression in thymocytes and memory T cells

Research Project

Project/Area Number 22790460
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionKyoto University

Principal Investigator

TANI-ICHI Shizue  京都大学, ウイルス研究所, 助教 (50432331)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsリンパ球 / サイトカインレセプター / 免疫学 / サイトカイン
Research Abstract

IL-7 is a cytokine essential for T lymphocyte development and homeostasis. However, little is known about the roles of itsα-chain(IL-7Rα) in late stages of T cell development. To address this question, we established IL-7Rα-floxed mice and crossed them with CD4-Cre transgenic mice. Resultant mice(IL-7RcKO) mice exhibited marked reduction in CD8 single positive(SP) T cells, regulatory T cells(Tregs) and natural killer T(NKT) cells. In addition, the proportion and proliferation of both mature CD4SP and CD8SP thymocytes were decreased, and expression of genes important for function of each subset was decreased. IL-7RcKO mice also showed impaired Treg and NKT cell proliferation and inhibition of NKT cell maturation. IL-7RcKO mice exhibited increased numbers of B,γδT, and dendritic cells in thymus. Overall, this study demonstrates that IL-7Rαhas multiple functions in thymocyte subpopulations in late developmental stages and suggests that IL-7R expression onαβT cells suppresses development of other cell lineages in thymus.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (13 results)

All 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (9 results) Remarks (1 results)

  • [Journal Article] The pre-TCR signal induces transcriptional silencing of the TCRγ locus by reducing the recruitment of STAT5 and Runx to transcriptional enhancers2011

    • Author(s)
      Tani-ichi, S., Satake, M., Ikuta, K.
    • Journal Title

      Int.Immunol.

      Volume: 23 Issue: 9 Pages: 553-563

    • DOI

      10.1093/intimm/dxr055

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Accessibility control of TCR Vγregion by STAT52010

    • Author(s)
      Tani-ichi, S., Lee, H.-C., Ye, S.-K., and Ikuta, K.
    • Journal Title

      Int. Immunol

      Volume: 22 Issue: 8 Pages: 693-703

    • DOI

      10.1093/intimm/dxq054

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Accessibility control of TCR Vγ region by STAT52010

    • Author(s)
      Tani-ichi, S., Lee, H.-C., Ye, S.-K., Ikuta, K.
    • Journal Title

      International Immunology

      Volume: 22 Pages: 693-703

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] A conserved enhancer element controls the expression of IL-7 receptorα-chain in peripheral T cells2011

    • Author(s)
      阿部昌史、谷一靖江、生田宏一
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Function of IL-7R in the late stage of T cell development2011

    • Author(s)
      谷一靖江、生田宏一
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Function of IL-7 receptor in the late stage of T cell development2011

    • Author(s)
      谷一靖江
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2011-11-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] T細胞分化の後期におけるIL-7Rの機能2011

    • Author(s)
      谷一靖江、生田宏一
    • Organizer
      第21回Kyoto T Cell Conference
    • Place of Presentation
      京都
    • Year and Date
      2011-06-10
    • Related Report
      2011 Final Research Report
  • [Presentation] IL-7Rα鎖遺伝子の近位エンハンサーは末梢T細胞のIL-7Rの発現を制御する2011

    • Author(s)
      阿部昌史、谷一靖江、生田宏一
    • Organizer
      第21回Kyoto T Cell Conference
    • Place of Presentation
      京都
    • Year and Date
      2011-06-10
    • Related Report
      2011 Final Research Report
  • [Presentation] T細胞分化の後期におけるIL-7Rの役割2011

    • Author(s)
      谷一靖江
    • Organizer
      第21回Kyoto T Cell Conference
    • Place of Presentation
      京都平安ホテル(京都府)
    • Year and Date
      2011-06-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] IL-7Rsignal controls differentiation of CD8 Tcells and maintenance of peripheral T cells2010

    • Author(s)
      Abe, A., Tani-ichi, S., and Ikuta, K.
    • Organizer
      The 14th International Congress of Immunology
    • Place of Presentation
      Kobe
    • Year and Date
      2010-08-25
    • Related Report
      2011 Final Research Report
  • [Presentation] IL-7R signal controls differentiation of CD8 T cells and maintenance of preripheral T cells2010

    • Author(s)
      A.Abe, S.Tani-ichi, K.Ikuta
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      神戸国際会議場・展示場
    • Year and Date
      2010-08-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular mechanism of TCRγsilencing2010

    • Author(s)
      Tani-ichi, S., and Ikuta, K.
    • Organizer
      The 14th International Congress of Immunology
    • Place of Presentation
      Kobe
    • Year and Date
      2010-08-24
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.virus.kyoto-u.ac.jp/Lab/ikuta.html

    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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