Immune induction mechanism by innate immune responses in vivo
| Project/Area Number |
22790461
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | 独立行政法人医薬基盤研究所 |
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Principal Investigator |
AOSHI Taiki 独立行政法人医薬基盤研究所, 創薬基盤研究部, 研究員 (10324344)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 自然免疫 / 感染症 / 免疫学 |
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| Research Abstract |
In this study, we examined the role of innate immunity for inducing adaptive immune responses against live influenza infection and influenza vaccine immunization using various innate immune receptor/adaptor knock-out mice. Our results showed that CD4T and antibody responses were strongly dependent on TLR7 signaling in pDCs. In contrast, CD8T responses against live influenza virus infection were independent of either TLR7, IPS-1, or ASC. These result suggested that each effector arm of adaptive immune responses were differently regulated by innate immune responses. Our results indicate that more specific stimulation of appropriate innate immunity may help to reduce adverse effects associated with vaccination.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] CD8α(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes2011
Author(s)
Edelson BT, Bradstreet TR, Hildner K, Carrero JA, Frederick KE, KC W, Belizaire R, Aoshi T, Schreiber RD, Miller MJ, Murphy TL, Unanue ER, Murphy KM
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Journal Title
Immunity
Volume: 35(2)
Issue: 2
Pages: 236-48
DOI
Related Report
Peer Reviewed
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[Journal Article] A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity2011
Author(s)
Fujimoto K, Karuppuchamy T, Takemura N, Shimohigoshi M, Machida T, Haseda Y, Aoshi T, Ishii KJ, Akira S, Uematsu S
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Journal Title
J Immunol
Volume: 1
Issue: 11
Pages: 6287-6295
DOI
Related Report
Peer Reviewed
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[Journal Article] Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes2010
Author(s)
Koyama S, Aoshi T, Tanimoto T, Kumagai Y, Kobiyama K, Tougan T, Sakurai K, Coban C, Horii T, Akira S, Ishii KJ
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Journal Title
Sci Transl Med
Volume: 2
Issue: 25
Pages: 24-25
DOI
Related Report
Peer Reviewed
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[Journal Article] Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes.2010
Author(s)
Koyama S, Aoshi T, Tanimoto T, Kumagai Y, Kobiyama K, Tougan T, Sakurai K, Coban C, Horii T, Akira S, Ishii KJ.
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Journal Title
Science Translational Medicine
Volume: 2
Related Report
Peer Reviewed
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