| Project/Area Number |
22790464
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
OGURA Hideki 大阪大学, 大学院・医学系研究科, 助教 (20573174)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | IL-6アンプ / IL-6 Amp / 4ステップモデル / 自己免疫 / 慢性炎症 / 線維芽細胞 / IL-17 / Ccl20 / 自己免疫疾患 / 関節炎 / IL-17A / CCL20 / IL-6 / IL-6Amp |
|---|
| Research Abstract |
IL-6 Amp is important for autoimmune diseases and chronic inflammation. In order to identify the target molecules of IL-6 Amp, several genome-wide screening methods were carried out. As results, an inflammatory chemokine Ccl20 that enhances the recruitment of a subset of T cells is identified as a key target. With those findings," a four-step model" for organ-specific autoimmune diseases was presented. Finally, a soluble molecule highly presented in the patients with an autoimmune disease was found to be important for regulating IL-6 Amp, that opens new possibilities for the drug development.
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