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Roles of lymph node stromal cell network in T cell homeostasis

Research Project

Project/Area Number 22790467
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionThe University of Tokushima

Principal Investigator

TAKADA Kensuke  徳島大学, 疾患ゲノム研究センター, 講師 (40570073)

Research Collaborator TAKAHAMA Yousuke  徳島大学, 疾患ゲノム研究センター, 教授 (20183858)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords獲得免疫 / T細胞 / ストローマ細胞
Research Abstract

As an initial step of a long-term project to understand the place of T cell homeostasis, we aimed to establish the classification of stromal cells constituting peripheral lymphoid tissues and to identify stromal cell subsets involved in the homeostasis of T cells. Stromal cells in the thymus and lymph nodes were analyzed for the expression of various molecular markers generally used for the classification of epithelial cells, blood endothelial cells, mesenchymal cells and mesenchymal stem cells. We found that alpha smooth muscle actin is potentially useful to classify fibroblastic reticular cells and perivascular cells which are thought to be important for T cell homeostasis.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (18 results)

All 2012 2011 2010

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (12 results)

  • [Journal Article] Beta5t-containing thymoproteasome : specific expression in thymic cortical epithelial cells and role in positive selection of CD8+ T cells2012

    • Author(s)
      Takahama Y
    • Journal Title

      Current Opinion in Immunology

      Volume: 24 Issue: 1 Pages: 92-98

    • DOI

      10.1016/j.coi.2012.01.006

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] β5t-containing thymoproteasome : specific expression in thymic cortical epithelial cells and role in positive selection of CD8+T cells2012

    • Author(s)
      Takaharaa Y, et al
    • Journal Title

      Current Opinion in Immunology

      Volume: 24 Pages: 92-98

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kruppel-like factor 2 is required for trafficking but not quiescence in postactivated T cells2011

    • Author(s)
      Takada K, Wang X, Hart GT, Odumade, OA, Weinreich MA, Hogquist KA and Jameson SC
    • Journal Title

      Journal of Immunology

      Volume: 186 Issue: 2 Pages: 775-783

    • DOI

      10.4049/jimmunol.1000094

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Another zinc finger in the pie of CD4-CD8 lineage choice2010

    • Author(s)
      Takada K and Takahama Y
    • Journal Title

      Nature Immunology

      Volume: 11 Issue: 5 Pages: 370-371

    • DOI

      10.1038/ni0510-370

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Another zinc finger in the pie of CD4-CD8 lineage choice.2010

    • Author(s)
      Takada K, et al.
    • Journal Title

      Nature Immunology

      Volume: 11号 Pages: 370-371

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kruppel-like factor 2 is required for trafficking but not quiescence in postactivated T cells.2010

    • Author(s)
      Takada K, et al.
    • Journal Title

      Journal of Immunology

      Volume: 186号 Pages: 775-783

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] β5t欠損マウスにおける末梢CD8T細胞の解析2011

    • Author(s)
      高田健介、高浜洋介
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Final Research Report
  • [Presentation] β5t欠損マウスにおける末梢CD8T細胞の解析2011

    • Author(s)
      高田健介, 他
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胸腺プロテアソーム非依存的に分化したCD8T細胞の機能解析2011

    • Author(s)
      高田健介、高浜洋介
    • Organizer
      第151回日本獣医学会学術集会
    • Place of Presentation
      大阪府立大学(大阪)
    • Year and Date
      2011-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 胸腺プロテアソーム非依存的に分化したCD8T細胞の機能解析2011

    • Author(s)
      高田健介, 他
    • Organizer
      第151回日本獣医学会学術集会
    • Place of Presentation
      大阪府立大学(大阪府)
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胸腺プロテアソーム構成因子β5t欠損マウスに認められるメモリー様CD8T細胞2011

    • Author(s)
      高田健介、高浜洋介
    • Organizer
      Kyoto T Cell Conference
    • Place of Presentation
      京都大学(京都)
    • Year and Date
      2011-06-11
    • Related Report
      2011 Final Research Report
  • [Presentation] 胸腺プロテアソーム構成因子β5t欠損マウスに認められるメモリー様CD8T細胞2011

    • Author(s)
      高田健介, 他
    • Organizer
      第21回Kyoto T Cell Conference
    • Place of Presentation
      京都平安ホテル(京都府)
    • Year and Date
      2011-06-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Memory-like phenotype of CD8 T cells inβ5t-deficient mice2011

    • Author(s)
      Takada K, Nitta T and Takahama Y
    • Organizer
      EUThyme-Rolduc Meeting
    • Place of Presentation
      NH Conference Center(オランダ、アムステルダム)
    • Year and Date
      2011-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Memory-like phenotype of CD8 T cells in β5t-deficient mice2011

    • Author(s)
      Takada K, et al
    • Organizer
      EUThyme-Rolduc Meeting
    • Place of Presentation
      NH Conference Center(オランダ)
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Kruppel-like factor 2 is dispensable for the quiescence of post-activated T cells2010

    • Author(s)
      Takada K, Hart GT, Odumade OA, Weinreich MA, Hogquist KA and Jameson SC
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe Convention Center(神戸)
    • Year and Date
      2010-08-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Kruppel-like factor 2 is dispensable for the quiescence of post-activated T cells2010

    • Author(s)
      Takada K, et al.
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Year and Date
      2010-08-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胸腺プロテアソーム構成因子β5t非依存的に分化したCD8T細胞の抗原特異性2010

    • Author(s)
      高田健介、新田剛、高浜洋介
    • Organizer
      第21回Kyoto T Cell Conference
    • Place of Presentation
      京都大学(京都)
    • Year and Date
      2010-06-10
    • Related Report
      2011 Final Research Report
  • [Presentation] 胸腺プロテアソーム構成因子β5t非依存的に分化したCD8T細胞の抗原特異性2010

    • Author(s)
      高田健介, 他
    • Organizer
      Kyoto T Cell Conference
    • Place of Presentation
      京都大学芝蘭会館(京都府)
    • Year and Date
      2010-06-04
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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