Immunoregulation and therapeutic application of IL-17-producing gamm delta T cells
Project/Area Number |
22790468
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Immunology
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Research Institution | Kyushu University |
Principal Investigator |
SHIBATA Kensuke 九州大学, 生体防御医学研究所, 助教 (50529972)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 粘膜免疫 / IL-17産生gd T細胞 / サイトカイン / T細胞 |
Research Abstract |
IL-17-producing gd T cells are involved in not only host defense against pathogens but also pathogenesis of various autoimmune diseases. We found that Notch-Hes1 pathway is critically involved in the development of IL-17-producing gd T cells. Furthermore, in infection mouse model with an opportunistic fungi, Candida albicans, IL-17-producing gd T cells had a protective role in the early stage of host defense by inducing neutrophil infiltration. Thus, our study provides a novel insight of development and function of IL-17-producing gd T cells.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Notch-Hes1 pathway is required for the development of IL-17-producing gammadelta T cells2011
Author(s)
Shibata K, Yamada H, Sato T, Dejima T, Nakamura M, Ikawa T, Hara H, Yamasaki S, Kageyama R, Iwakura Y, Kawamoto H, Toh H, Yoshikai Y.
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Journal Title
Blood
Volume: 118
Pages: 586-93
Related Report
Peer Reviewed
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