| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Research Abstract |
Majority of IgA+ B cells are induced in germinal centers (GCs) of Peyer's patches (PPs) depend on the function of follicular B helper T cells (TFH cells). TFH cells express high amount of the inhibitory receptor PD-1. The absence of PD-1 led to the expansion of PP TFH cells with different properties (over production of IFN-gamma and less production of IL-21) that caused disturbed repertoire of GC B cells. Thus, PD-1-/- mice had reduced affinity maturation of IgA producing plasma cells, and less binding capacity of secreted IgA on the surface of commensal bacteria in the gut, which led to the disturbed gut microbial communities in PD-1-/- mice. The dysbiosis induced over-activation of the systemic immune system with lymphocyte hyperplasia. Thus, TFH cells play critical roles to sustain GC B cells in PPs and to maintain the homeostasis of the immune system in our whole body.
|
