Analysis for the role of follicular B helper T cells in the maintenance of germinal center B cells
Project/Area Number |
22790479
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Immunology
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Research Institution | Kyoto University (2011-2013) The Institute of Physical and Chemical Research (2010) |
Principal Investigator |
SUZUKI Keiichiro 京都大学, 医学(系)研究科(研究院), 准教授 (90391995)
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Project Period (FY) |
2010-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 濾胞性BヘルパーT細胞 / IgA / パイエル板 / 腸内細菌 / 濾胞性ヘルパーT細胞細胞 / PD-1 / AID / 腸管免疫組織 / 全身免疫組織 / B細胞 / T_<TH>細胞 / 胚中心 / 細胞周期 / T細胞 |
Research Abstract |
Majority of IgA+ B cells are induced in germinal centers (GCs) of Peyer's patches (PPs) depend on the function of follicular B helper T cells (TFH cells). TFH cells express high amount of the inhibitory receptor PD-1. The absence of PD-1 led to the expansion of PP TFH cells with different properties (over production of IFN-gamma and less production of IL-21) that caused disturbed repertoire of GC B cells. Thus, PD-1-/- mice had reduced affinity maturation of IgA producing plasma cells, and less binding capacity of secreted IgA on the surface of commensal bacteria in the gut, which led to the disturbed gut microbial communities in PD-1-/- mice. The dysbiosis induced over-activation of the systemic immune system with lymphocyte hyperplasia. Thus, TFH cells play critical roles to sustain GC B cells in PPs and to maintain the homeostasis of the immune system in our whole body.
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Report
(5 results)
Research Products
(27 results)
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[Journal Article] Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age2011
Author(s)
Qin H, Suzuki K, Nakata M, Chikuma S, Izumi N, Huong le T, Maruya M, Fagarasan S, Busslinger M, Honjo T, Nagaoka H
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Journal Title
NAID
Related Report
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[Journal Article] Activation-induced cytidina deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age2011
Author(s)
Qin H, Suzuki K, Nakata M, Chikuma S, Izumi N, Huong le T, Maruya M, Fagarasan S, Busslinger M, Honjo T, Nagaoka H
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Journal Title
Related Report
Peer Reviewed
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