| Project/Area Number |
22790483
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
NAKAGAWA Reiko 独立行政法人理化学研究所, 幹細胞研究グループ, 専門職研究員 (40469911)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | パイエル板 / CXCR4 / リンホトキシン / Lymphoid tissue inducer(LTi) / Lymphoid tissue inducer cell / Peyer's Patch |
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| Research Abstract |
Peripheral lymphoid tissues such as lymph nodes and Peyer's patches are the organs where all cellular components required for immune response are assembled around the antigen processing cells. In order to mount efficient immune reactions against a small dose of antigen, a highly organized tissue architecture with distinct zones for T and B cells have to be developed. In this study, we present the evidence that lymphoid tissue inducer cells that initially play the pivotal role in the formation of PP anlagen are involved in the formation of B and T cell zones in neonatal mice. In order to migrate over different zones, PPi undergoes chemokine receptor switches.
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