Research Project
Grant-in-Aid for Young Scientists (B)
The goal of this study is to achieve high-efficiency delivery of intravenously injected mesenchymal stem cells(MSCs) into the injured brain. We developed an in vitro culture system consisting of rat brain microvascular endothelial cells(BMECs) and bone marrow-derived MSCs. Live cell imaging using this system revealed that MSCs transmigrated across BMEC monolayers via a paracellular route. In addition, inhibition of MAP kinases affected transmigration of MSCs across BMEC monolayers.
All 2012 2011 2010
All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (9 results)
Neurosci Lett
Volume: 502 Issue: 1 Pages: 41-45
10.1016/j.neulet.2011.07.021