Development of Alzheimer's disease therapeutics mediate for enhancement of synaptic transmission
| Project/Area Number |
22790509
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | sunifiram / LTP / CaMキナーゼII / NMDA受容体グリシン結合部位 / OBXマウス / 電気生理学 / PKC / 認知機能 / アルツハイマー病 / NMDA受容体 / DM232 / memantine / 認知機能調節 / グリシン結合部位 |
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| Research Abstract |
Sunifiram is a new pyrrolidone nootropic drug structurally related to piracetam, being development for neurodegenerative disorder like Alzheimer's disease. Sunifiram modulates glycine binding site of NMDAR concomitant increased PKC・activity through Src family kinase. Enhancement of PKC・activity triggered to potentiates hippocampal LTP through activation of CaMKII.
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Report
(3 results)
Research Products
(38 results)
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[Journal Article] Reduced expression of the ATRX gene, a chromatin-remodeling factor2011
Author(s)
Tatsuya Nogami, Hideyuki Beppu, Takashi Tokoro, Shigeki Moriguchi, Norifumi Shioda, Kohji Fukunaga, Toshihisa Ohtsuka, Yoko Ishii, Masakiyo Sasahara, Yutaka Shimada, Hisao Nishijo, En Li and Isao Kitajima
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Journal Title
causes hippocampal dysfunction in mice
Volume: 21
Pages: 678-687
Related Report
Peer Reviewed
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[Journal Article] Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice2011
Author(s)
Tatsuya Nogami, Hideyuki Beppu, Takashi Tokoro, Shigeki Moriguchi, Norifumi Shioda, Kohji Fukunaga, Toshihisa Ohtsuka, Yoko Ishii, Masakiyo Sasahara, Yutaka Shimada, Hisao Nishijo, En Li, Isao Kitajima
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Journal Title
Hippocampus
Volume: 21
Pages: 678-687
Related Report
Peer Reviewed
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[Journal Article] Essential role of meuron-enriched diacylglycerol kinase (DGK), DGKβ in neurite spine formation, contributing to cognitive function.2010
Author(s)
Yasuhito Shirai, Takeshi Kouzuki, Kenichi Kakefuda, Shigeki Moriguchi, Atsushi Oyagi, Kyoji Horie, Shin-ya Morita, Masamitsu Shimazawa, Kohji Fukunaga, Junji Kakeda, Naoaki Saito, Hideaki Hara
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] A novel cognitive enhancer, spino[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446/ST101), promotes hippocampal neurogenesis and ameliorates depressive behavior in olfactory bulbectomized mice.2010
Author(s)
Norifumu Shioda, Yui Yamamoto, Feng Han, Shigeki Moriguchi, Yoshimasa Yamaguchi, Masataka Hino, Kohji Fukunaga
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Journal Title
J.Pharmacol.Exp.Ther.
Volume: 333
Pages: 43-50
Related Report
Peer Reviewed
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