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Feasibility study of developing bone formative drugs with regulating Wnt signaling.

Research Project

Project/Area Number 22790510
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Applied pharmacology
Research InstitutionThe University of Tokyo

Principal Investigator

MIURA Shogo  東京大学, 医学部・附属病院, 特任助教 (90529182)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsシグナル伝達 / 発現制御 / 生体分子 / 骨粗鬆症 / 骨芽細胞 / 骨形成 / Wnt / LRP5/6 / Wnt-βcateninシグナル
Research Abstract

Wnt/Fzd signaling has been believed to play a critical role inosteoblast differentiation although the detailed manner was not obviously clarified. In this study, it has been revealed that not only the activation ofβ-catenin pathway, an already known critical pathway, but also the suppression of JNK pathway contributes to osteoblast differentiation. The balance of the activation of these two pathways is likely to be regulated by the quantity of LRP molecules available to form a complex with Wnt ligands. It is also suggested that Wnt molecules regulate subcellular localization of LRP. The relationship between Wnt signaling and LRP subcellular behavior may be a promising clue to elucidate the mystery of Wnt signaling in osteoblast differentiation.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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