X-ray crystallographic analysis of an ABC transporter
| Project/Area Number |
22790512
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Kyoto University |
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Principal Investigator |
KODAN Atsushi 京都大学, 物質.細胞統合システム拠点, 研究員 (80360543)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 生体分子 / 蛋白質 / 薬学 / 癌 / ABC蛋白質 / X線結晶構造解析 / 創薬 |
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| Research Abstract |
Understanding the mechanism of action of ABC proteins and developing new therapeutic strategies that target ABC proteins would be considerably accelerated with the three-dimensional structures. Crystal structure of an exporter-type ABC transporter from a unicellular eukaryote was determined by the multiwavelength anomalous dispersion(MAD) method using the X-ray diffraction data measured at SPring-8. The resolution obtained in this study is best among those of eukaryotic ABC proteins ever reported to date.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Deleting two C-terminal α-helices is effective to crystallize the bacterial ABC transporter Escherichia coli MsbA complexed with AMP-PNP.2010
Author(s)
Terakado, K., Kodan, A., Nakano, H., Kimura, Y., Ueda, K., Nakatsu, T., Kato, H.
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Journal Title
Acta Crystallographica Section D-Biological Crystallography
Volume: D66
Pages: 319-323
Related Report
Peer Reviewed
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