| Project/Area Number |
22790513
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Research Collaborator |
YAMAMOTO Akira 京都薬科大学, 薬学部, 教授 (00166779)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | ドラッグデリバリー / 薬学 / 薬剤学 / 薬物送達システム / 経皮吸収 / 皮膚 / ゾレドロネート / 癌骨転移 / 骨疾患 |
|---|
| Research Abstract |
Bisphosphonates are widely used for the treatment of bone diseases. In this study, we successfully developed a novel transdermal patch of zoledronate, a nitrogen-containing bisphosphonate, for the treatment of bone metastasis. The zoledronate patch effectively reduced the number of tumor cells in the bone in model mice with bone metastasis.
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