| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Research Abstract |
We examined the improvement of proteinuria in the 5/6 nephrectomy model (Nx) and the effect of an association between an AT-1 receptor blocker, losartan (L), and megalin. The proteinuria insignificant decreased to Nx model rat treated with L as compared with Nx model rats. We demonstrated that megalin reduced in Nx model rat kidney by immunohistochemistry using anti-megalin antibody. On the other hands, expression of megalin recovered to sham level in Nx model rat treated with L. Megalin is a multiligand endocytotic receptor involving in the reabsorption of low molecular weight proteins in renal proximal tubule. Accordingly, this data suggest that rescue of megalin expression were contributed to improvement of proteinuria.
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