| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Antimicrobial peptides(AMPs) are secreted from intestinal epithelium cell as the starting point for infection, contribute to innate immunity in the intestinal tract. We investigated that the 2-arachidonylglycerol(2-AG) secretes AMPs and that injection of 2-AG suppresses infection of pathogenic microorganism. The present study showed that 2-AG secreted the AMPs from Caco-2 cells. Furthermore, 2-AG suppressed the total number of E. coli marker during 6-hour period. Taken together, we found that 2-AG might suppress against pathogenic microorganism infection by secreting AMPs from intestinal epithelium cells.
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