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Establishment of the Enhancement Effect of 2-Arachidonylglycerol on Antimicrobial Peptide Induction

Research Project

Project/Area Number 22790516
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Applied pharmacology
Research InstitutionFukuoka University

Principal Investigator

IRIE Keiichi  福岡大学, 加齢脳科学研究所, 研究員 (50509669)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords2-アラキドノイルグリセロール / 抗菌ペプチド / カンナビノイド
Research Abstract

Antimicrobial peptides(AMPs) are secreted from intestinal epithelium cell as the starting point for infection, contribute to innate immunity in the intestinal tract. We investigated that the 2-arachidonylglycerol(2-AG) secretes AMPs and that injection of 2-AG suppresses infection of pathogenic microorganism. The present study showed that 2-AG secreted the AMPs from Caco-2 cells. Furthermore, 2-AG suppressed the total number of E. coli marker during 6-hour period. Taken together, we found that 2-AG might suppress against pathogenic microorganism infection by secreting AMPs from intestinal epithelium cells.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (12 results)

All 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (8 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Trace metal zinc stimulates secretion of antimicrobial peptide LL-37 from Caco-2 cells through ERK and p38 MAP kinase2010

    • Author(s)
      Parimal Talukder, Tomomitsu Satho, Keiichi Irie, Tanjina Sharmin, Dieng Hamady, Yukihiko Nakashima, Nobuhiro Kashige, Fumio Miake
    • Journal Title

      International Immunopharmacology

      Volume: 11(1) Pages: 141-144

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Trace metal zinc stimulates secretion of antimicrobial peptide LL-37 from Caco-2 cells through ERK and p38 MAP kinase2010

    • Author(s)
      Talukder P., et al.
    • Journal Title

      Int Immunopharmacol

      Volume: 11(1) Pages: 141-144

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 2-Arachidonylglycerol protects against infection by secretion of antimicrobial peptides from the intestinal tract2011

    • Author(s)
      Saori Uyeda, Keiichi Irie, Takahiro Okuno, Shodai Tsuruda, Mari Ioki, Yukie Tamura, Tomomitsu Satho, Kenichi Miahima, Yukihiko Nakashima, Nobuhiro Kashige, Fumio Miake
    • Organizer
      International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      北海道
    • Year and Date
      2011-09-07
    • Related Report
      2011 Final Research Report
  • [Presentation] 2-Arachidonylglycerol protects against infection by secretion of antimicrobial peptides from the intestinal tract2011

    • Author(s)
      Saori Uyeda, et al
    • Organizer
      International Union of Microbiological Societies 2011 Congress (IUMS 2011)
    • Place of Presentation
      北海道,札幌コンベンションセンター
    • Year and Date
      2011-09-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] ウコン含有成分クルクミンが腸管の自然免疫に与える影響2011

    • Author(s)
      赤司唯、頭島美幸、入江圭一、佐藤朝光、中島幸彦、三島健一、藤原道弘、鹿志毛信広、見明史雄
    • Organizer
      第28回和漢医薬学会学術大会
    • Place of Presentation
      富山
    • Year and Date
      2011-08-27
    • Related Report
      2011 Final Research Report
  • [Presentation] ウコン含有成分クルクミンが腸管の自然免疫に与える影響2011

    • Author(s)
      赤司唯, et al
    • Organizer
      第28回和漢医薬学会学術大会
    • Place of Presentation
      富山,富山県民会館
    • Year and Date
      2011-08-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 2-arachidonylglycerolの腸管病原微生物に対する感染防御への有効性2011

    • Author(s)
      上田沙織、入江圭一、佐藤朝光、三島健一、鶴田翔大、五百木真里、田村幸恵、奥野隆啓、中島幸彦、岩崎克典、鹿志毛信広、藤原道弘、見明史雄
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 脂肪酸によるヒト腸管上皮細胞からの抗菌ペプチドLL-37の発現誘導2011

    • Author(s)
      飯岡利規、入江圭一、Talukder Parimal、佐藤朝光、中島幸彦、鹿志毛信広、見明史雄
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 脂肪酸によるヒト大腸上皮細胞からの抗菌ペプチドLL-37の発現誘導2011

    • Author(s)
      飯岡利規, et al.
    • Organizer
      第131年会日本薬学会
    • Place of Presentation
      静岡,ツインメッセ静岡
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 2-arachidonoylglycerolの病原微生物に対する感染防御への有効性2011

    • Author(s)
      上田沙織, et al.
    • Organizer
      第131年会日本薬学会
    • Place of Presentation
      静岡,ツインメッセ静岡
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 生体試料中2-アラキドノイルグリセロールの定量法2010

    • Inventor(s)
      入江圭一、藤原道弘、三島健一、樋口聖、三島健司、早川和秀、佐野和憲、佐藤朝光、秋武義治、荒木舞子、大治万喜子
    • Industrial Property Rights Holder
      福岡大学
    • Industrial Property Number
      2010-234486
    • Filing Date
      2010-10-19
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 生体内試料中2-アラキドノイルグリセロールの定量法2010

    • Inventor(s)
      入江圭一
    • Industrial Property Rights Holder
      福岡大学
    • Industrial Property Number
      2010-234486
    • Filing Date
      2010-10-19
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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