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The individualization of breast cancer by stem cell properties and search of new marker for classification

Research Project

Project/Area Number 22790520
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Laboratory medicine
Research InstitutionTohoku University

Principal Investigator

ITO Takako  東北大学, 大学院・医学系研究科, 助教 (10375173)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords腫瘍検査学 / 乳癌 / 幹細胞 / 個別化 / 癌幹細胞 / 癌
Research Abstract

In this study, the relation between stemness properties of spheroids prepared from primary breast cancers and clinicopathological findings was investigated. Luminal breast cancer could be separated into two subclasses by stemness-related gene expression, and NANGO-high type was predicted to be high stemness properties and high grade tumors. This classification could be useful and a novel criterion for subclassification of luminal breast cancers.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (12 results)

All 2012 2011 2010 Other

All Presentation (12 results)

  • [Presentation] Heterogeneity ofLuminal-type Brest Cancer and Cancer Stemness2012

    • Author(s)
      伊藤貴子
    • Organizer
      15th International Congress on Hormonal Steroids and Hormones & Cancer
    • Place of Presentation
      金沢
    • Year and Date
      2012-11-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 乳癌組織分離細胞の癌幹細胞性の検討2012

    • Author(s)
      伊藤貴子
    • Organizer
      第71回癌学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 癌幹細胞性によるLuminal型乳癌の新たな個別化2012

    • Author(s)
      伊藤貴子
    • Organizer
      第20回日本乳癌学会学術総会
    • Place of Presentation
      熊本
    • Year and Date
      2012-06-28
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 乳癌組織分離細胞の癌幹細胞性の検討とintrinsic subtypeとの相関2011

    • Author(s)
      伊藤貴子
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2012 Final Research Report
  • [Presentation] 乳癌組織分離細胞の癌幹細胞性の検討とintrinsic subtypeとの相関2011

    • Author(s)
      伊藤貴子
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 乳癌組織分離細胞の癌幹細胞性の検討と臨床病理学的因子との相関2011

    • Author(s)
      伊藤貴子
    • Organizer
      第19回日本乳癌学会
    • Place of Presentation
      宮城
    • Year and Date
      2011-09-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 乳癌組織分離細胞の癌幹細胞性の検討と臨床病理学的因子との相関2011

    • Author(s)
      伊藤貴子
    • Organizer
      第19回日本乳癌学会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Year and Date
      2011-09-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 乳癌原発腫瘍における癌幹細胞の解析2010

    • Author(s)
      伊藤貴子
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 乳癌原発腫瘍における癌幹細胞の解析2010

    • Author(s)
      伊藤貴子
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 乳癌組織からの癌幹細胞の同定・培養の試みと臨床病理学的因子との相関2010

    • Author(s)
      伊藤貴子
    • Organizer
      第18回日本乳癌学会
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 乳癌組織分離細胞の癌幹細胞性の検討

    • Author(s)
      伊藤貴子
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] Heterogeneity of Luminal-type Brest Cancer and Cancer Stemness.

    • Author(s)
      伊藤貴子
    • Organizer
      15th International Congress on Hormonal Steroids and Hormones & Cancer
    • Place of Presentation
      金沢
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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