The individualization of breast cancer by stem cell properties and search of new marker for classification
| Project/Area Number |
22790520
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
ITO Takako 東北大学, 大学院・医学系研究科, 助教 (10375173)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 腫瘍検査学 / 乳癌 / 幹細胞 / 個別化 / 癌幹細胞 / 癌 |
|---|
| Research Abstract |
In this study, the relation between stemness properties of spheroids prepared from primary breast cancers and clinicopathological findings was investigated. Luminal breast cancer could be separated into two subclasses by stemness-related gene expression, and NANGO-high type was predicted to be high stemness properties and high grade tumors. This classification could be useful and a novel criterion for subclassification of luminal breast cancers.
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Report
(4 results)
Research Products
(12 results)
