| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
For treatment of leukemia, it is necessary to assess antileukemia agent by precise drug sensitivity test. We assumed that cell culture system in hypoxia mimicking bone marrow microenvironment is useful for assess the effect than the system in normoxia. In this study, we found that hypoxia culture system upregurated HIF protein expression as well as affected Notch, NF-kB, and mTOR signaling in leukemia stem cells. We established a basis for a new drug sensitivity test in hypoxia.
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