Diagnostic value of immunohistochemical expression of IMP3 in transpapillary biliary forceps biopsy samples of extrahepatic bile duct carcinoma

• Project/Area Number: 22790525
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Laboratory medicine
• Research Institution: Nagoya University
• Principal Investigator: KAWASHIMA Hiroki 名古屋大学, 医学系研究科, 助教 (20378045)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 経乳頭的胆管生検 / ERCP / 胆管癌 / 胆道癌 / IMP3 / S100P / 免疫染色 / 胆管生検 / 診断 / IMP3免疫染色 / 病理組織学的診断

Research Abstract

The objective of this study is to clarify the diagnostic and prognostic value of immunohistochemical expression of S100P andIMP3 in transpapillary biliary forceps biopsy (TBFB) samples. The TBFB samples were collected from 80 patients (extrahepatic bile duct carcinoma, 68 patients; benign, 12 patients), retrospectively. The sensitivity, specificity and accuracy achieved 89.7 %, 91.7 % and 90.0 %, respectively, when using positive staining for IMP3and/or positive histology as a maker of malignancy. While univariate (P= 0.033) and multivariate (P= 0.039) analysis revealed that S100P-positive extrahepatic bile duct carcinoma patients showed significantly shorter survival.

Research Products

• [Journal Article] Diagnostic and prognostic value of immunohistochemical expression of S100P and IMP3 in transpapillary biliary forceps biopsy samples of extrahepatic bile duct carcinom (2013)
  • Author(s): Kawashima H, Itoh A, Ohno E, Miyahara R, Ohmiya N, Tanaka T, Shimoyama Y,Nakamura S, bata T, Nagino M, Goto H, Hirooka Y
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 20 Pages: 441-447
  • Peer Reviewed
• [Journal Article] Diagnostic and prognostic value of immunohistochemical expression of S100P and IMP3 in transpapillary biliary forceps biopsy samples of extrahepatic bile duct carcinoma. (2013)
  • Author(s): Kawashima H
  • Journal Title: J Hepatobiliary Pancreat Sci. Volume: 20 Issue: 4 Pages: 441-447
  • DOI: 10.1007/s00534-012-0581-z
  • NAID: 10031168243
  • Peer Reviewed
• [Journal Article] Is nasobiliary drainage unnecessary for drainage of acute suppurative cholangitis? our experience (2010)
  • Author(s): Hiroki Kawashima
  • Journal Title: Digestive Endoscopy Volume: 22
  • NAID: 10028188046
  • Peer Reviewed
• [Presentation] IMP3 とS100P による経乳頭的胆管生検組織免疫染色の臨床病理学的検討 (2012)
  • Author(s): 川嶋啓揮、廣岡芳樹、伊藤彰浩、大野栄三郎、伊藤裕也、中村陽介、平松武、杉本啓之、鷲見肇、舩坂好平、中村正直、宮原良二、大宮直木、後藤秀実
  • Organizer: 第54回日本消化器病学会大会
  • Place of Presentation: 神戸
• [Presentation] 経乳頭的胆管生検組織のIMP3とS100P免疫染色の検討 (2011)
  • Author(s): 川嶋啓揮
  • Organizer: 第53回日本消化器病学会大会(JDDW 2011)
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-21
• [Presentation] 経乳頭的胆管生検組織の病理診断におけるIMP3免疫染色の有用性の検討 (2011)
  • Author(s): 川嶋啓揮
  • Organizer: 第47回日本胆道学会学術集会
  • Place of Presentation: 宮崎
  • Year and Date: 2011-09-16
• [Presentation] 広範囲肝切除を必要とする悪性肝門部胆道狭窄に対する内視鏡的経鼻胆道ドレナージと経乳頭的胆管生検 (2011)
  • Author(s): 川嶋啓揮
  • Organizer: 第81回日本消化器内視鏡学会総会
  • Place of Presentation: 青森市民文化会館(青森県)(発表確定)
  • Year and Date: 2011-04-21
• [Presentation] 経乳頭的胆管生検組織の IMP3 と S100P 免疫染色の検討 (2011)
  • Author(s): 川嶋啓揮、廣岡芳樹、伊藤彰浩、大野栄三郎、松原浩、伊藤裕也、中村陽介、平松武、杉本啓之、鷲見肇、田中努、中村正直、宮原良二、大宮直木、後藤秀実
  • Organizer: 第53回日本消化器病学会大会
  • Place of Presentation: 福岡
• [Presentation] 川嶋啓揮、伊藤彰浩、大野栄三郎、松原浩、伊藤裕也、中村陽介、平松武、杉本啓之、鷲見肇、後藤秀実、廣岡芳樹 (2011)
  • Author(s): 経乳頭的胆管生検組織の病理診断におけるIMP3 免疫染色の有用性の検討
  • Organizer: 第47回 日本胆道学会学術集会
  • Place of Presentation: 宮崎
• [Presentation] THE RISK FACTORS OF PANCREATITIS AND CHOLANGITIS AFTER ENDOSCOPIC NASOBILIARY DRAINAGE FOR MALIGNANT HILAR BILIARY OBSTRUCTION (2010)
  • Author(s): Hiroki Kawashima
  • Organizer: UEGW 2010
  • Place of Presentation: CCIB Congress Center(バルセロナ)
  • Year and Date: 2010-10-27
• [Presentation] 胆道癌術前の片葉内視鏡的経鼻胆道ドレナージ (2010)
  • Author(s): 川嶋啓揮
  • Organizer: 第80回日本消化器内視鏡学会総会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2010-10-16
• [Presentation] 経乳頭的胆管生検による胆管狭窄病変診断の実際 (2010)
  • Author(s): 川嶋啓揮
  • Organizer: 第79回日本消化器内視鏡学会総会
  • Place of Presentation: グランドプリンスホテル新高輪(東京)
  • Year and Date: 2010-05-13