Study on the mechanism of hypertension via endogenous digitalis-like factor in central nervous system
| Project/Area Number |
22790534
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory medicine
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 内因性ジギタリス / 高血圧 / 生理活性物質 / 質量分析 / 脳 / 神経 / 視床下部 / 副腎 / 培養細胞 / アルドステロン / ELISA / HPLC |
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| Research Abstract |
Endogenous digitalis-like factor(EDLF) exist in the central nerve system as well as peripheral tissue. Ouabain is existed in hypothalamus and regulated by renin angiotensin aldosterone system(RAAS). A novel EDLF belonged to bufadienolide may be secreted from hypothalamus immortalized cell line. Moreover angiotensin should regulate to secret marinobufagenin and marinobufotoxin from adrenal gland.
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Report
(3 results)
Research Products
(25 results)
