Role of IL-18 in diabetes mellitus.

• Project/Area Number: 22790535
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Laboratory medicine
• Research Institution: Hyogo Medical University
• Principal Investigator: EGUCHI Hironobu 兵庫医科大学, 医学部, 助教 (60351798)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 臨床化学 / 糖尿病 / IL-18 / 糖化反応 / 活性酸素 / アディポネクチン / バイオマーカー / AGE / サイトカイン

Research Abstract

The purpose of this study was to investigate the relationship between oxidative stress and cytokines in diabetes mellitus and find the disease-specific marker. It was revealed that the reactive oxygen species(ROS), including hydrogen peroxide, nitric oxide and peroxynitrite, enhanced the nitric oxide production via the expression of interferon beta. This mechanism may be involved in the development of diabetes.

Research Products

• [Journal Article] Hydrogen peroxide enhances LPS-induced nitric oxide production via the expression of interferon beta in BV-2 microglial cells. (2011)
  • Author(s): Eguchi H, Fujiwara N, Sakiyama H, Yoshihara D, Suzuki K.
  • Journal Title: Neurosci Lett Volume: 494(1) Issue: 1 Pages: 29-33
  • DOI: 10.1016/j.neulet.2011.02.047
  • Peer Reviewed
• [Journal Article] Hydrogen peroxide enhances LPS-induced nitric oxide production via the expression of interferon beta in BV-2 cells (2011)
  • Author(s): Hironobu Eguchi
  • Journal Title: Neuroscience Letters Volume: 494 Pages: 29-33
  • Peer Reviewed
• [Presentation] Accelerated production of nitric oxide by LPS and hydrogen peroxide in BV-2 microglial cells (2011)
  • Author(s): Hironobu Eguchi
  • Organizer: 5^<th> Biennial Meeting of Society for Free Radical Research-Asia(SFRR-Asia)
  • Place of Presentation: Kagoshima
  • Year and Date: 2011-09-03
• [Presentation] Accelerated production of nitric oxide by LPS and Hydrogen peroxide in BV-2 microglial cells (2011)
  • Author(s): Hironobu Eguchi
  • Organizer: 5^<th> Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia)
  • Place of Presentation: 鹿児鳥市民文化ホール(鹿児鳥県)
  • Year and Date: 2011-09-03
• [Presentation] 過酸化水素はIFN-βの発現を介してLPSによるNO産生を増強する (2011)
  • Author(s): 江口裕伸
  • Organizer: 第58回日本生化学会近畿支部例会
  • Place of Presentation: 大阪
  • Year and Date: 2011-05-21
• [Presentation] 過酸化水素はIFN-βの発現を介してLPSによるNO産生を増強する (2011)
  • Author(s): 江口裕伸
  • Organizer: 第58回日本生化学会近畿支部例会
  • Place of Presentation: 関西医科大学滝井キャンパス(大阪府)
  • Year and Date: 2011-05-21
• [Presentation] 過酸化水素はLPSによるNO産生を増強する (2010)
  • Author(s): 江口裕伸
  • Organizer: 第83回日本生化学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-08