| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
The profile of protein phosphorylation in colon malignant tumor tissues were compared with those in colon benign tumor and non-tumor tissues using a phospho-proteomic technique(Phospho-iTRAQ). Phosphorylation levels at more than 200 phosphorylation sites were altered in the malignant tumor tissues, suggesting that these alterations are candidates for colon cancer. To validate these candidates, a phospho-SI-SRM technique was developed. Using these proteomic techniques and bioinformatics, I identified candidate biomarkers for colon cancer and signaling proteins involved in colon cancer.
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