Genetic and epigenetic differences in cholesterol kinetics in relation to NASH development between SHRSP and SHRSP5/Dmcr rat
Project/Area Number |
22790543
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Hygiene
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Research Institution | Nagoya University |
Principal Investigator |
NAITO Hisao 名古屋大学, 大学院・医学系研究科, 助教 (90547556)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 肝線維化 / 非アルコール性脂肪性肝疾患 / コレステロール / 胆汁酸 / 核内受容体 / トリグリセライド / BSEP / MRP3 / 薬物代謝酵素 / HRP3 |
Research Abstract |
This study aims to clarify the differences in molecular mechanisms of the cholesterol and bile acid kinetics in the progression of high fat-cholesterol diet(HFC)-induced steatohepatitis and fibrosis between SHRSP5/Dmcr and SHRSP rats. In the result, SHRSP5/Dmcr may be more susceptible to liver fibrosis than SHRSP, which may be resulted from the higher intracellular accumulation of cytotoxic bile acid by decreased BSEP expression, though increased MRP3.
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Report
(3 results)
Research Products
(45 results)
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[Journal Article] Modulation of hepatic adenosine triphosphate and inflammation by eicosapentaenoic acid under severe fibrosis progression in SHRSP5/Dmcr2012
Author(s)
Jia X, Naito H, Yetti H, Tamada H, Kitamori K, Hayashi Y, Yamagishi N, Wang D, Yanagiba Y, Ito Y, Wang J, Tanaka N, Ikeda K, Yamori Y, Nakajima T
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Journal Title
Life Sci
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Simultaneous changes in high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis and those underlying molecular mechanisms in novel SHRSP5/Dmcr rat2012
Author(s)
Moriya T, Kitamori K, Naito H, Yanagiba Y, Ito Y, Yamagishi N, Tamada H, Jia X, Tsuchikura S, Ikeda K, Yamori Y, Nakajima T
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Modulation of ammonium perfluorooctanoate-induced hepatic damage by genetically different PPARαin mice.2012
Author(s)
Nakagawa T, Ramdhan DH, Tanaka N, Naito H, Tamada H, Ito Y, Li YF, Hayashi Y, Yamagishi N, Yanagiba Y, Aoyama T, Gonzalez FJ, Nakajima T
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Journal Title
Arch Toxicol
Volume: 86
Issue: 1
Pages: 63-74
DOI
Related Report
Peer Reviewed
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[Journal Article] Development of novel rat model for high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis progression in SHRSP5/Dmcr2011
Author(s)
Kitamori K, Naito H, Tamada H, Kobayashi M, Miyazawa D, Yasui Y, Sonoda K, Tsuchikura S, Yasui N, Ikeda K, Moriya T, Yamori Y, Nakajima T
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Hepatic peroxisome proliferator-activated receptor α may have an importantrole in the toxic effects of di(2-ethylhexyl)phthalate on offspring of mice.2011
Author(s)
Hayashi Y, Ito Y, Yamagishi N, Yanagiba Y, Tamada H, Wang D, Ramdhan DH, Naito H, Harada Y, Kamijima M, Gonzales FJ, Nakajima T.
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Journal Title
Toxicology
Volume: (印刷中 未定)
Related Report
Peer Reviewed
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[Journal Article] Differential Response to Trichloroethylene-Induced Hepatosteatosis in Wild-Type and PPARalpha-Humanized Mice.2010
Author(s)
Ramdhan DH, Kamijima M, Wang D, Ito Y, Naito H, Yanagiba Y, Hayashi Y, Tanaka N, Aoyama T, Gonzalez FJ, Nakajima T.
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Journal Title
Environmental Health Perspective
Volume: 118(11)
Pages: 1557-1563
Related Report
Peer Reviewed
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