The association between BNP level, NPPB genotype and CVD risk in general Japanese population.

• Project/Area Number: 22790544
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Hygiene
• Research Institution: Shiga University of Medical Science
• Principal Investigator: TAKASHIMA Naoyuki 滋賀医科大学, 医学部, 特任助教 (80435883)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: NPPB遺伝子多型 / 脳性ナトリウム利尿ペプチド / 左室肥大 / 循環器疾患発症 / 予防医学 / 循環器・高血圧 / 社会医学 / 分子疫学

Research Abstract

Brain natriuretic peptide (BNP) is a clinical useful marker forheart failure. In the present study, we observed the significant association between plasma BNP levels and electrocardiographic left ventricular hypertrophy. However, we did not find the significant association between electrocardiographic left ventricular hypertrophy and the NPPB genotype. Furthermore, we did not find any significant association between the NPPB genotype and future cardiovascular disease risk. Therefore, it is needed for further research to examine the association between CVD risk and the NPPB genotype.