| Project/Area Number |
22790545
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Hygiene
|
|---|
| Research Institution | Waseda University (2011)
Osaka University (2010) |
|---|
Principal Investigator |
SHIRATO Ken 早稲田大学, 人間科学学術院, 助手 (60559384)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Keywords | 気道上皮 / 創傷治癒 / Hypoxia-inducible factor(HIF)-1α / 細胞生理学 / 分子生物学 / 低酸素誘導因子(HIF)-1α / HIF-1α |
|---|
| Research Abstract |
When airway epithelial cells were stimulated by scratch wound, hypoxia-inducible factor(HIF)-1α is accumulated into the nucleus of the cells located at the wound margin. HIF-1α deprivation promoted wound healing of airway epithelial cells. By contrast, HIF-1α inducer suppressed wound healing of the cells, and this effect was attenuated by HIF-1α deprivation. These results suggest that scratch wound-induced HIF-1α is a negative regulator for wound healing of airway epithelial cells.
|
