| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Study purpose is to search the biomarkers indicating relations of the childhood allergies and environmental factors.
[Material and Methods] We did questionnaire survey and the measurement of the specific IgE levels, serum level of PCBs and mRNA by using the children's blood.
[Result] We extracted 30 preschool children (healthy children 15, asthmatic children 15) from subjects (N=200). (1) IL-8 mRNA expression was high in the children who were asthma and had high level of PCB concentration. (2) IL-22mRNA expression was high in the children who were IgE positive and had high level of PCB concentration.
[Conclusion] Our results suggested that the possibility that IL-8 and IL -22 were useful biomarkers for environmental exposure in allergic children.
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