| Project/Area Number |
22790547
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
TOMOSUGI Mano (HORINAKA Mano) 京都府立医科大学, 大学院・医学研究科, 助教 (80512037)
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|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 癌 / TRAIL / DR5 / アポトーシス / 予防 / タンパク質分泌機構 / 併用 |
|---|
| Research Abstract |
We evaluated whether several immunomodulators stimulated the release of TRAIL from PMNs. As a result, Clostridium butyricum MIYAIRI 588(CBM588) increased soluble TRAIL levels in the culture supernatant of PMNs. Interestingly, TLR2/4 signaling pathway has been suggested to be important for the release of TRAIL by MMP-8.We demonstrated that CBM588 enhanced the cytotoxicity of PMNs against human bladder cancer cells. In addition, CBM588 has proven effective against cancer cells by inducing apoptosis in vivo as well as in vitro.
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