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Endoplasmic reticulum stress-induced fetal growth retardation is associated with placental dysfunction

Research Project

Project/Area Number 22790551
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Hygiene
Research InstitutionTokushima Bunri University

Principal Investigator

KAWAKAMI Takashige  徳島文理大学, 薬学部, 助教 (40441589)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords小胞体ストレス / 胎盤 / 胎仔発育遅延 / グルコーストランスポーター / 胎児発育遅延
Research Abstract

In order to investigate the effect of endoplasmic reticulum(ER) stress on placental function and fetal growth, the pregnant mice were treated with daily injections of tunicamycin(Tun) at doses of 20, 40, and 60μg/kg/day from gestation day(GD) 12.5 to GD16.5.Tun treatment decreased the weight of placenta and fetus. Furthermore, Tun treatment increased placental Slc2a3/GLUT3 mRNA expression level, which is one of the major placental glucose transporter, while it decreased the Slc2a1/GLUT1 mRNA expression level. Sodium 4-phenylbutyrate, a chemical chaperone, protects against endoplasmic reticulum stress-induced intrauterine growth retardation in mice. These results suggest that continuous exposure to ER stress disrupts glucose supply from dam to fetus via placenta, at least in part, with altered expressions of glucose transporters resulting in low birth weight.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (21 results)

All 2012 2011 2010 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (12 results) Remarks (3 results)

  • [Journal Article] Differential effects of cobalt and mercury on lipid metabolism in the white adipose tissue of high-fat diet-induced obesity mice2012

    • Author(s)
      Kawakami T, Hanao N, Nishiyama K, Kadota Y, Inoue M, Sato M, Suzuki S.
    • Journal Title

      Toxicol Appl Pharmacol

      Volume: 258(1) Pages: 32-42

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential effects of cobalt and mercury on lipid metabolism in the white adipose tissue of high-fat diet-induced obesity mice2012

    • Author(s)
      Kawakami T, Hanao N, Nishiyama K, Kadota Y, Inoue M, Sato M, Suzuki S
    • Journal Title

      Toxicol Appl Pharmacol

      Volume: 258(1) Issue: 1 Pages: 32-42

    • DOI

      10.1016/j.taap.2011.10.004

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early changes induced by environmental stresses in insulin sensitivity-related genes2011

    • Author(s)
      Sato M, Ishibashi S, Higashimoto M, Kadota Y, Kawakami T, Suzuki S.
    • Journal Title

      Eur J Pharmacol

      Volume: 668(3) Pages: 472-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Early changes induced by environmental stresses in insulin sensitivity-related genes2011

    • Author(s)
      M.Sato, S.Ishibashi, M.Higashimoto, Y.Kadota, T.Kawakami, S.Suzuki
    • Journal Title

      European Journal of Pharmacology

      Volume: 668 Issue: 3 Pages: 472-476

    • DOI

      10.1016/j.ejphar.2011.07.034

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of high-fat-diet-induced obesity in female metallothionein-null mice2010

    • Author(s)
      Sato M, Kawakami T, Kondoh M, Takiguchi M, Kadota Y, Himeno S, Suzuki S.
    • Journal Title

      FASEB J

      Volume: 24(7) Pages: 2375-84

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of high-fat-diet-induced obesity in female metallothionein-null mice.2010

    • Author(s)
      佐藤政男、川上隆茂
    • Journal Title

      FASEB J

      Volume: 24(7) Pages: 2375-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 化学シャペロンの胎盤内グルコース動態改善を介した小胞体ストレスによるマウス胎仔発育遅延の抑制2012

    • Author(s)
      川上隆茂
    • Organizer
      日本薬学会第131回年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 脂肪細胞関連遺伝子Mestは脂肪細胞分化時に発現が増大する2012

    • Author(s)
      門田佳人、川上隆茂
    • Organizer
      日本薬学会第131回年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] 小胞体ストレス誘導性低体重仔に対する化学シャペロンの抑制効果2011

    • Author(s)
      川上隆茂
    • Organizer
      日本薬学会第131回年会
    • Place of Presentation
      静岡
    • Related Report
      2011 Final Research Report
  • [Presentation] 小胞体ストレスによる胎仔発育および胎盤内血管形成への影響2011

    • Author(s)
      川上隆茂
    • Organizer
      フォーラム2011衛生薬学・環境トキシコロジー
    • Place of Presentation
      金沢
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 母体への小胞体ストレス負荷による胎盤・母体および胎仔肝臓中のメタロチオネイン誘導2011

    • Author(s)
      川上隆茂
    • Organizer
      メタロチオネイン及びメタルバイオサイエンス研究会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 脂肪細胞肥大化促進遺伝子Mestのマウス培養脂肪細胞分化誘導時における発現変動に関する研究2011

    • Author(s)
      門田佳人、川上隆茂
    • Organizer
      フォーラム2011衛生薬学・環境トキシコロジー
    • Place of Presentation
      金沢
    • Related Report
      2011 Annual Research Report
  • [Presentation] メタロチオネイン欠損マウスを用いた高脂肪食摂取に対する肥満発症の性差発現メカニズム解析2011

    • Author(s)
      川上隆茂
    • Organizer
      メタロチオネイン及びメタルバイオサイエンス研究会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] メタロチオネイン欠損マウス由来脂肪細胞株を用いた脂肪細胞レベルでのカドミウムの影響解析2011

    • Author(s)
      川上隆茂
    • Organizer
      メタロチオネイン及びメタルバイオサイエンス研究会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] 正常および肥大化脂肪組織に対する金属の脂質蓄積およびエネルギー代謝への影響2011

    • Author(s)
      川上隆茂
    • Organizer
      メタロチオネイン及びメタルバイオサイエンス研究会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] 小胞体ストレス誘導性低体重仔に対する化学シャペロンの抑制効果2011

    • Author(s)
      川上隆茂
    • Organizer
      日本薬学会
    • Place of Presentation
      静岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小胞体ストレス負荷による胎盤形態異常と胎仔発育遅延発症メカニズム2010

    • Author(s)
      川上隆茂
    • Organizer
      日本薬学会・中国四国支部学術大会
    • Place of Presentation
      米子
    • Year and Date
      2010-11-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 母体における持続的な小胞体ストレスは胎盤胎仔間グルコース輸送を破綻させ低体重仔を発症させる2010

    • Author(s)
      吉見允貴、川上隆茂
    • Organizer
      フォーラム2010衛生薬学・環境トキシコロジー
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Remarks]

    • URL

      http://p.bunri-u.ac.jp/lab11/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://p.bunri-u/ac.jp/lab/lab11/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://p.bunri-u.ac.jp/lab11/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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